Effect of Intravenous Lidocaine and Dexamethasone Combination on Postoperative Sore Throat, Cough and Hoarseness.
NCT ID: NCT01990781
Last Updated: 2016-11-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE4
180 participants
INTERVENTIONAL
2013-12-31
2016-01-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Both non pharmacological and pharmacological measures have been tried to minimize the incidence and severity of POST with variable success rate. Prophylactic use lidocaine and steroids have been used independently for this purpose. Dexamethasone as an adjuvant to lidocaine has shown to improve the quality of analgesia. However, there is no study assessing the combine effects of lidocaine and dexamethasone for POST.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Keywords
Explore important study keywords that can help with search, categorization, and topic discovery.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Group LD: Lidocaine and Dexamethasone
lidocaine 1.5 mg/kg and dexamethasone (dexona) 8 mg iv prior to induction of anesthesia
LD: Lidocaine and dexamethasone
LD: intravenous lidocaine 1.5 mg/kg and dexamethasone 8 mg before induction of anesthesia
Group L: Lidocaine
Group L: lidocaine 1.5 mg/kg iv prior to induction of anesthesia
L:Lidocaine
Intravenous lidocaine 1.5 mg/kg before induction of anesthesia
D: Dexamethasone
Dexamethasone 8 mg iv prior to induction of anesthesia
D: Dexamethasone
D:intravenous dexamethasone 8 mg before induction of anesthesia
N: normal saline
N: normal saline (placebo): 2 ml
N: Normal saline (placebo)
Normal saline: 2ml
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
LD: Lidocaine and dexamethasone
LD: intravenous lidocaine 1.5 mg/kg and dexamethasone 8 mg before induction of anesthesia
L:Lidocaine
Intravenous lidocaine 1.5 mg/kg before induction of anesthesia
D: Dexamethasone
D:intravenous dexamethasone 8 mg before induction of anesthesia
N: Normal saline (placebo)
Normal saline: 2ml
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Duration of surgery more than 90 min
Exclusion Criteria
* Smoker
* Vocal performer by occupation
* Recent or recurrent respiratory tract infection
* Risk factors for postoperative aspiration
* Obesity
* Pregnancy
* Receiving analgesics, corticosteroids and calcium channel blockers
* Contraindication to corticosteroid medications
* Anticipated difficult intubation
* Mallampati grade \> 2
* Difficult mask ventilation requiring oral or nasal airway
* Cormack and Lehman grade III and IV on laryngoscopy
* More than one intubation attempt
* Those requiring orogastric or nasogastric tubes
18 Years
65 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
B.P. Koirala Institute of Health Sciences
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Dr Asish Subedi
Associate Professor, Department of Anesthesiology, BPKIHS
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Asish Subedi, MD
Role: PRINCIPAL_INVESTIGATOR
BPKIHS
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
BP Koirala Institute of Health Sciences (BPKIHS)
Dharān, Koshi, Nepal
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Subedi A, Tripathi M, Pokharel K, Khatiwada S. Effect of Intravenous Lidocaine, Dexamethasone, and Their Combination on Postoperative Sore Throat: A Randomized Controlled Trial. Anesth Analg. 2019 Jul;129(1):220-225. doi: 10.1213/ANE.0000000000003842.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
387/070/071
Identifier Type: -
Identifier Source: org_study_id