Willingness to Participate in Clinical Trials Among Black and African Americans

NCT ID: NCT04938895

Last Updated: 2023-05-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 323 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-06-07
• Study Completion Date: 2022-02-21

Brief Summary

Despite significant racial disparities in health outcomes, racial minority groups in the United States are not adequately represented in clinical trials, and clinical trial results published in major medical journals often underreport racial demographic data of participants. Lack of diversity in clinical trials threatens the generalizability of study results and reduces the ability of minority groups to benefit from medical advancement and innovation. Prior studies show that Black men are more likely to engage in preventive services when there is racial concordance with their healthcare provider. There is minimal literature about how racial concordance or diversity in clinical trial leadership impacts study enrollment. This project examines whether patients' willingness to participate in randomized clinical trials differs based on the characteristics of the investigator.

Detailed Description

We plan to recruit subjects and randomly assign them to one of four treatments. In each treatment arm, the subject will view a photograph of a real NIH investigator. We experimentally vary treatment along two dimensions: whether the sender is Black or white and whether the sender is male or female.

Our primary aim is to assess whether the subject's stated willingness to participate in a clinical trial led by the investigator. Our secondary aim is to assess whether the subject is a more objective measure of interest in signing up for information on other clinical trials. To assess mechanisms, we will ask the respondent to rate the subject's perceived trustworthiness and quality of the investigator. In addition, we will also assess the subject's perceived attractiveness and age of the investigator as well as the subject's risk aversion, altruism, time preference, and general trust.

Conditions

Researcher-Subject Relations

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: SINGLE

Study Groups

Black Woman Investigator

Survey respondents are exposed to a Black woman investigator.

Group Type: EXPERIMENTAL

Black Respondents Exposure to a Photo

Intervention Type: BEHAVIORAL

Black survey respondents will be randomly assigned to one of four treatments. In each treatment arm, the subject will view a photo of an NIH investigator. We experimentally vary treatment along two dimensions: whether the investigator is a man v. woman and whether the man is white vs. black. We will survey participants' willingness to participate in a clinical trial and how their initial response is impacted by other characteristics such as perceived trustworthiness and quality.

Black Man Investigator

Survey respondents are exposed to a Black man investigator.

Group Type: EXPERIMENTAL

Black Respondents Exposure to a Photo

Intervention Type: BEHAVIORAL

Black survey respondents will be randomly assigned to one of four treatments. In each treatment arm, the subject will view a photo of an NIH investigator. We experimentally vary treatment along two dimensions: whether the investigator is a man v. woman and whether the man is white vs. black. We will survey participants' willingness to participate in a clinical trial and how their initial response is impacted by other characteristics such as perceived trustworthiness and quality.

White Woman Investigator

Survey respondents are exposed to a white woman investigator.

Group Type: EXPERIMENTAL

Black Respondents Exposure to a Photo

Intervention Type: BEHAVIORAL

Black survey respondents will be randomly assigned to one of four treatments. In each treatment arm, the subject will view a photo of an NIH investigator. We experimentally vary treatment along two dimensions: whether the investigator is a man v. woman and whether the man is white vs. black. We will survey participants' willingness to participate in a clinical trial and how their initial response is impacted by other characteristics such as perceived trustworthiness and quality.

White Man Investigator

Survey respondents are exposed to a white man investigator.

Group Type: EXPERIMENTAL

Black Respondents Exposure to a Photo

Intervention Type: BEHAVIORAL

Black survey respondents will be randomly assigned to one of four treatments. In each treatment arm, the subject will view a photo of an NIH investigator. We experimentally vary treatment along two dimensions: whether the investigator is a man v. woman and whether the man is white vs. black. We will survey participants' willingness to participate in a clinical trial and how their initial response is impacted by other characteristics such as perceived trustworthiness and quality.

Interventions

Black Respondents Exposure to a Photo

Black survey respondents will be randomly assigned to one of four treatments. In each treatment arm, the subject will view a photo of an NIH investigator. We experimentally vary treatment along two dimensions: whether the investigator is a man v. woman and whether the man is white vs. black. We will survey participants' willingness to participate in a clinical trial and how their initial response is impacted by other characteristics such as perceived trustworthiness and quality.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• participant identifies as Black or White

Exclusion Criteria

• participant doesn't identify as Black or White
• younger than 25 years old, older than 64

• Minimum Eligible Age: 25 Years
• Maximum Eligible Age: 64 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Harvard University

OTHER

Sponsor Role: lead

Responsible Party

Marcella Alsan

Professor of Public Policy

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Marcella Alsan, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Harvard University

Locations

Harvard University

Cambridge, Massachusetts, United States

Countries

United States

Other Identifiers

IRB21-0864

Identifier Type: -

Identifier Source: org_study_id