Crossover Trial to Assess Efficacy and Safety of Inhaled AQ001S Compared to a Budesonide Suspension in Mild Asthmatics

NCT ID: NCT04933383

Last Updated: 2024-09-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 23 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-07-23
• Study Completion Date: 2023-01-31

Brief Summary

This is a prospective, active-controlled, randomized, open label, single-center, multiple dose, two-period crossover clinical trial to assess the efficacy, safety and pharmacokinetics of AQ001S compared to a budesonide inhalation suspension (comparator) in adults with mild asthma.

Both treatments will be administered by nebulization.

Detailed Description

Adults patients with mild asthma (18 to 65 years old), who are 'inhaled corticosteroid (ICS)'-naïve for minimum 60 days at Screening Visit will be enrolled in the study. The patients will be treated for 28 days. The primary endpoint will be assessed by a provocative concentration of methacholine that results in a 20% drop (PC20) in the first second forced expiratory volume (FEV1) as determined by methacholine challenge test. The pharmacokinetics (PK) endpoint, i.e. PK profile of budesonide in plasma, and pharmacodynamics (PD) endpoints, i.e. recording of symptom scores, use of reliever drugs as needed, biomarkers of airway inflammation and pulmonary function tests will be assessed during the study.

Conditions

Asthma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

AQ001S 0.125 mg/ml

AQ001S 0.125 mg/ml is a budesonide inhalation solution administered by nebulization once daily.

Group Type: EXPERIMENTAL

AQ001S 0.125 mg/ml

Intervention Type: DRUG

administered by nebulization once daily

Budesonide 0.125 mg/ml inhalation suspension

Intervention Type: DRUG

administered by nebulization once daily

budesonide inhalation suspension 0.125 mg/ml

Budesonide 0.125 mg/ml is a budesonide inhalation suspension administered by nebulization once daily.

Group Type: ACTIVE_COMPARATOR

AQ001S 0.125 mg/ml

Intervention Type: DRUG

administered by nebulization once daily

Budesonide 0.125 mg/ml inhalation suspension

Intervention Type: DRUG

administered by nebulization once daily

Interventions

AQ001S 0.125 mg/ml

administered by nebulization once daily

Intervention Type: DRUG

Budesonide 0.125 mg/ml inhalation suspension

administered by nebulization once daily

Intervention Type: DRUG

Other Intervention Names

budesonide inhalation solution 0.125 mg/ml; Budesonide inhalation suspension 0.125 mg/ml

Eligibility Criteria

Inclusion Criteria

• Body mass index between 18.5 and 29 kg/m2.
• Documented clinical diagnosis of stable, persistent, asthma for at least 3 months
• Subjects who are ICS-naïve for minimum 60 days at Screening Visit.
• Positive methacholine (MCh) challenge test (concentration of MCh provoking an FEV1 fall of 20% [PC20] < 8 mg/ml or dose of MCh provoking an FEV1 fall of 20% [PD20] < 0.2 mg) in the last year.
• Post-bronchodilator FEV1 at least 80% of the predicted, documented in the last year.
• Clinical laboratory test results, 12-lead electrocardiogram (ECG), blood pressure and heart rate (supine) within normal reference range or judged to be not clinically significant by the Investigator.
• Female subjects of childbearing potential should have a negative pregnancy test at Screening Visit and use a highly effective method of contraception.
• Reliable subjects who are willing to be available for the duration of the clinical trial and willing to comply with clinical trial procedures.
• Subjects who have the ability to understand the requirements of the clinical trial.
• Subjects who have given written informed consent.

Exclusion Criteria

• Current smokers or recent (< 8 weeks) ex-smokers or ex-smokers if > 10 pack-years.
• Pregnant or breastfeeding female subjects.
• Inability to carry out pulmonary function testing.
• FEV1 < 70%.
• History of near-fatal asthma and/or intensive care unit admission for asthma symptoms.
• Exacerbations of asthma requiring oral steroids, hospitalization or change in asthma treatment in the previous three months.
• Evidence of symptomatic chronic or acute respiratory infection in the previous 8 weeks.
• Diagnosis of chronic obstructive pulmonary disease (COPD) or bronchiectasis.
• Pulmonary malformations, tuberculosis, cystic fibrosis.
• History of hypersensitivity or existing contraindication to budesonide or any other Investigational Medicinal Product (IMP) ingredients.
• Untreated oral candidiasis.
• Immunosuppressive treatment, including systemic corticosteroids (e.g., oral, parenteral, ocular, nasal), within 28 days before Screening Visit.
• Use of ICS within 60 days before Screening Visit.
• Use of anti-leukotrienes, immunoglobulins, beta-blockers, digitalis, amiodarone, antifungals, macrolides, antidepressants, monoamine oxidase inhibitors, antiretroviral drugs, cholinesterase inhibitors, histamine, theophylline, non-steroidal anti-inflammatory drugs, anticholinergic drugs, neuroleptics, curariform drugs, antihistaminic (anti-H1) drugs, calcium channel blockers, long acting beta2-antagonists, mast cell stabilizers (e.g. natrium cromoglycate).
• History of alcohol or drug abuse.
• Unstable or life-threatening cardiac disease
• History or presence of prolonged QT interval (> 470 ms), or any other clinically significant ECG abnormalities as judged by the Investigator based on 12-lead ECG recordings at Screening Visit.
• Diabetes mellitus.
• Neuropsychiatric diseases.
• Clinically relevant laboratory abnormalities at Screening Visit.
• Blood or plasma donation within 30 days prior to Screening Visit.
• History or presence of malignancy of any system organ class (other than localized basal cell carcinoma of the skin), treated or untreated, within the past 5 years prior to Screening Visit, regardless of whether there is evidence of local recurrence or metastases.
• Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of drugs, or which may jeopardize the subject in case of participation in the clinical trial.
• History or presence of any other clinically relevant disease of any major system organ class (e.g. cardiovascular, pulmonary, renal, hepatic, gastrointestinal, reproductive, endocrinological, neurological, psychiatric or orthopedic disease) as judged by the Investigator.
• Human immunodeficiency virus (HIV) and severe acute respiratory syndrome (SARS)-CoV-2 infections.
• Subjects who participated in an investigational trial within the 12 weeks prior to the start of the trial.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Aquilon Pharmaceuticals S.A.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jean-Benoît Martinot

Role: PRINCIPAL_INVESTIGATOR

Pneumocare SPRL

Locations

Pneumocare SPRL

Erpent, Namur, Belgium

Countries

Belgium

Provided Documents

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

AQ-PRO-005

Identifier Type: -

Identifier Source: org_study_id