ARTISS a Single-centre Randomised Control Study

NCT ID: NCT04931615

Last Updated: 2024-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

135 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-01

Study Completion Date

2023-02-28

Brief Summary

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The Influence of ARTISS on post-operative abdominal drainage and seroma formation in DIEP/MS-TRAM free flap breast reconstruction patients.

Detailed Description

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The principle aim of the study is to investigate the effect of ARTISS on abdominal wound drainage whether this could result in earlier drain removal and earlier patient discharge from hospital. The primary outcome investigated will be post- operative abdominal drainage duration in days which is vital information during this Covid pandemic to reduce hospital stay (and therefore possible Covid exposure) which could result in earlier discharge from hospital, as well as significantly reducing cost of the procedure to the NHS and frees in-patient beds for more efficient use of resources.

Conditions

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Breast Neoplasms Mammaplasty

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomised controlled trial
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors
Blinded patient and blinded assessor

Study Groups

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without ARTISS

Surgery performed without active comparative

Group Type PLACEBO_COMPARATOR

no ARTISS

Intervention Type OTHER

Wound closed without sealant

with ARTISS

Surgery performed with active comparative

Group Type ACTIVE_COMPARATOR

ARTISS 4mL Fibrin Sealant Topical Solution (Frozen)

Intervention Type DRUG

Wound sealant

Interventions

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ARTISS 4mL Fibrin Sealant Topical Solution (Frozen)

Wound sealant

Intervention Type DRUG

no ARTISS

Wound closed without sealant

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Female adult (age 18-80)
* Patients planned for immediate or delayed DIEP/MS-TRAM breast reconstruction

Exclusion Criteria

* Patients who are unable to consent or do not consent
* Clotting disorder
* Pregnancy
* Individuals whose immune system is depressed or who have some types of anaemia (e.g. sickle cell disease or haemolytic anaemia).
* COVID positive
* Known previous allergic reactions to ARTISS
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Mid and South Essex NHS Foundation Trust

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mary Morgan, MD

Role: STUDY_CHAIR

Mid and South Essex NHS Foundation Trust

Locations

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Mid and South Essex NHS Foundation Trust

Broomfield, Essex, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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2021-002624-20

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

287482

Identifier Type: -

Identifier Source: org_study_id

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