Effects of Music Beat on Motor Function in Individuals At Risk for Psychotic Onset and Schizophrenia Patients

NCT ID: NCT04929795

Last Updated: 2024-11-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-08-11
• Study Completion Date: 2023-12-31

Brief Summary

The purpose of this project is to investigate whether a 3-week training program involving music beat (serving as a type of rhythmic auditory stimulation) reduces the severity of bradykinesia and dyskinesia in at-risk individuals and schizophrenia patients. It is hypothesized that the program is effective in reducing the severity of bradykinesia and dyskinesia in at-risk individuals and schizophrenia patients.

Conditions

Schizophrenia; Psychosis; Parkinsonism; Dyskinesias

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

at risk- RAS

At-risk individuals in the experimental group will undergo upper-limb movement training with the aid of music beat serving as a type of rhythmic auditory stimulation (RAS).

Group Type: EXPERIMENTAL

Rhythmic auditory stimulation (RAS)

Intervention Type: BEHAVIORAL

The song named 'Sign of The Times' is played and recorded by the research personnel beforehand. The beat of the song will serve as RAS. The computer software "Audacity" will be used to adjust tempi of RAS. Before intervention, the participant is required to execute the movement task without the aid of RAS as quickly as possible for 30 seconds, so that we obtain his/her baseline movement tempo. For each 40-minute training session in the first training week, three RAS tempi will be provided for the first, second, and last 10 minutes with a five-minute break in between: normal (100% of the baseline tempo), quick (105% of the baseline tempo), and fast (110% of the baseline tempo). With each training week, the three RAS tempi will be increased by 5%. Participants in the experimental groups are required to use their right hand to pick up beads from source bowls to the target bowl when listening to the song. The 3-week intervention program will include 21 40-minute daily training sessions.

at risk- no RAS

At-risk individuals in the control group will receive upper-limb training without the aid of RAS.

Group Type: ACTIVE_COMPARATOR

no RAS

Intervention Type: BEHAVIORAL

The training protocol will be the same as that used in the experimental group except the lack of RAS during execution of the movement task.

schizophrenia- RAS

Schizophrenia patients in the experimental group will undergo upper-limb movement training with the aid of RAS.

Group Type: EXPERIMENTAL

Rhythmic auditory stimulation (RAS)

Intervention Type: BEHAVIORAL

The song named 'Sign of The Times' is played and recorded by the research personnel beforehand. The beat of the song will serve as RAS. The computer software "Audacity" will be used to adjust tempi of RAS. Before intervention, the participant is required to execute the movement task without the aid of RAS as quickly as possible for 30 seconds, so that we obtain his/her baseline movement tempo. For each 40-minute training session in the first training week, three RAS tempi will be provided for the first, second, and last 10 minutes with a five-minute break in between: normal (100% of the baseline tempo), quick (105% of the baseline tempo), and fast (110% of the baseline tempo). With each training week, the three RAS tempi will be increased by 5%. Participants in the experimental groups are required to use their right hand to pick up beads from source bowls to the target bowl when listening to the song. The 3-week intervention program will include 21 40-minute daily training sessions.

schizophrenia- no RAS

Schizophrenia patients in the control group will receive upper-limb training without the aid of RAS.

Group Type: ACTIVE_COMPARATOR

no RAS

Intervention Type: BEHAVIORAL

The training protocol will be the same as that used in the experimental group except the lack of RAS during execution of the movement task.

Interventions

Rhythmic auditory stimulation (RAS)

The song named 'Sign of The Times' is played and recorded by the research personnel beforehand. The beat of the song will serve as RAS. The computer software "Audacity" will be used to adjust tempi of RAS. Before intervention, the participant is required to execute the movement task without the aid of RAS as quickly as possible for 30 seconds, so that we obtain his/her baseline movement tempo. For each 40-minute training session in the first training week, three RAS tempi will be provided for the first, second, and last 10 minutes with a five-minute break in between: normal (100% of the baseline tempo), quick (105% of the baseline tempo), and fast (110% of the baseline tempo). With each training week, the three RAS tempi will be increased by 5%. Participants in the experimental groups are required to use their right hand to pick up beads from source bowls to the target bowl when listening to the song. The 3-week intervention program will include 21 40-minute daily training sessions.

Intervention Type: BEHAVIORAL

no RAS

The training protocol will be the same as that used in the experimental group except the lack of RAS during execution of the movement task.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

1. A score of or above 9 in the Chinese version of the 16-item Prodromal Questionnaire (CPQ-16), or a score of or above 8.18 in the Chinese version of Community Assessment of Psychic Experiences with 15 items (CAPE-C15), or a score of or above 17 in Schizotypal Personality Questionnaire-Brief (SPQ-B);

2. an age of 13 years or above;

3. score > 60 in The Chinese version of Edinburgh Handedness Inventory (CH-EBI) to ensure right handedness; and

4. score ≥ 22 in Montreal Cognitive Assessment Hong Kong Version (HK-MoCA) to ensure no serious cognitive deficits so that they can understand instructions.

1. a diagnosis of schizophrenia without other psychiatric diseases;

2. the age ≥ 18 years;

3. score > 60 in CH-EBI to ensure right handedness; and

4. score ≥ 22 in HK-MoCA to ensure no serious cognitive deficits so that they can understand instructions.

Exclusion Criteria

1. psychiatric diagnosis by self-report;

2. cardiovascular, neurological, muscular or orthopedic diseases that may affect hand movements;

3. taking psychiatric medications;

4. substance abuse; and

5. being pregnant.

For schizophrenia participants:

1. cardiovascular, neurological, muscular or orthopedic diseases that may affect hand movements;

2. substance abuse; and

3. being pregnant.

• Minimum Eligible Age: 13 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Dr WANG Shumei

OTHER

Sponsor Role: lead

Responsible Party

Dr WANG Shumei

Assistant Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

ST814, the Hong Kong Polytechnic University

Kowloon, , Hong Kong

Countries

Hong Kong

Other Identifiers

HSEARS20210610001

Identifier Type: -

Identifier Source: org_study_id