Characterizing the Effects of Family History of Alcoholism on Alcohol Analgesia

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

125 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-11-20

Study Completion Date

2023-06-01

Brief Summary

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Self-medication of pain with alcohol is a common, yet risky, behavior. Evidence suggests family history of alcoholism may affect the degree to which alcohol use relieves pain, but the independent contributions of expectation and conditioning have not been previously studied. Interactive effects of sex and family history are also currently unclear. This project addresses this gap in knowledge and will inform further research and clinical/translational efforts for reducing risk associated with these behaviors.

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Detailed Description

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Conditions

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Effects of Family History of Alcoholism and Sex on Alcohol Analgesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Participants will receive an active oral dose of alcohol or placebo in a counterbalanced manner.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Family History Positive

People reporting at least one parent with a history of alcohol problems.

Group Type EXPERIMENTAL

Ethanol

Intervention Type DRUG

A beverage containing dose of ethanol individually determined to raise a participant's breath alcohol concentration up to approximately 0.08 g/dL.

Placebo

Intervention Type OTHER

A beverage that does not meaningfully increase breath alcohol concentration.

Family History Negative

People who do not report having a parent with a history of alcohol problems.

Group Type EXPERIMENTAL

Ethanol

Intervention Type DRUG

A beverage containing dose of ethanol individually determined to raise a participant's breath alcohol concentration up to approximately 0.08 g/dL.

Placebo

Intervention Type OTHER

A beverage that does not meaningfully increase breath alcohol concentration.

Interventions

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Ethanol

A beverage containing dose of ethanol individually determined to raise a participant's breath alcohol concentration up to approximately 0.08 g/dL.

Intervention Type DRUG

Placebo

A beverage that does not meaningfully increase breath alcohol concentration.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

\- Consume at least 1 drink/month over the past 6 months

Exclusion Criteria

* History of chronic pain
* Current use of opioids
* Current major depression
* History of any psychotic disorder
* Undercontrolled hypertension or diabetes
* History of neurologic disease
* History of serious medical illness
* History of drug or alcohol dependence, including nicotine, or a pattern of hazardous alcohol use
* Safety concerns related to MRI (for example, implants or pacing devices)

Minimum Eligible Age

21 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes