Association of Hb F Level With Clinical Severity of Beta Thalassemia

NCT ID: NCT04917978

Last Updated: 2021-06-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-12-01

Study Completion Date

2025-12-30

Brief Summary

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The production of Hb F after birth is an important factor in modifying the clinical severity of beta thalassemia because an increased gamma-globin level will bind the additional a-globin and form Hb F. The objective of this project is to evaluate the association of Hb F level with phenotypic diversity of patients with beta thalassemia.

Detailed Description

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Conditions

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Beta Thalassemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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beta thalassemia patients

Hematological Phenotype Analysis

Intervention Type DIAGNOSTIC_TEST

Hematological parameters were determined with an automated hematology analyzer (Sysmex, Japan), and hemoglobin analysis was performed with either high-performance liquid chromatography (Bio- Rad, USA) or capillary electrophoresis (Sebia, France and Helena, USA).

Interventions

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Hematological Phenotype Analysis

Hematological parameters were determined with an automated hematology analyzer (Sysmex, Japan), and hemoglobin analysis was performed with either high-performance liquid chromatography (Bio- Rad, USA) or capillary electrophoresis (Sebia, France and Helena, USA).

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with beta-thalassemia

Exclusion Criteria

* Iron Deficiency Anemia
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ZhuHai Hospital

OTHER

Sponsor Role collaborator

Shenzhen Children's Hospital

OTHER_GOV

Sponsor Role collaborator

Shenzhen Second People's Hospital

OTHER

Sponsor Role collaborator

Jiangmen Maternity and Child Health Care Hospital

UNKNOWN

Sponsor Role collaborator

Yongzhou Maternity and Child Health Hospital

UNKNOWN

Sponsor Role collaborator

Nanfang Hospital, Southern Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Southern Medical University

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xiangmin Xu, Prof. Dr.

Role: CONTACT

02061648293 ext. 86

Facility Contacts

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Xiangmin Xu, Prof. Dr.

Role: primary

02061648293 ext. 86

Other Identifiers

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HbF-Beta thalassemia

Identifier Type: -

Identifier Source: org_study_id

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