Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-20

Study Completion Date

2022-04-25

Brief Summary

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While interdisciplinary weight loss intervention have been shown successful among adolescents with obesity, a weight regain is most of the time observed within the following weeks or months. The aim of the present project will be to better identify the independent role played by both the metabolic and mechanical load and their modification during weight loss, on the energy expenditure and energy metabolism of adolescents with obesity.

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Detailed Description

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A total of 28 adolescents with obesity will be recruited from our local inpatient pediatric obesity centers. Before their weight loss intervention the adolescents will complete two experimental visits. During the first visit, anthropometric and body composition measurements will be performed. Then the participants will be asked to complete a walking exercise on a treadmill during the second visit. Their energy expenditure and substrate oxidation will be assessed by indirect calorimetry. They will have to walk at 5 different walking speeds. Then, they will follow a 12-week weight loss intervention. By the end of this intervention, their body composition will be assessed and they will be asked to perform the same walking exercise. On a separate occasion (randomly assigned) they will have to repeat this walking exercise while carrying a load corresponding of their weight loss.

Conditions

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Pediatric Obesity

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

One group of adolescents with obesity

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

There is no need for masking here.

Study Groups

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Adolescents with obesity

Adolescents with obesity aged 12-16 years old

Group Type EXPERIMENTAL

Multidisciplinary weight loss

Intervention Type BEHAVIORAL

The adolescents will follow a 12-week intervention combining nutritional education, physical activity 3 times per week and psychological supports.

Interventions

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Multidisciplinary weight loss

The adolescents will follow a 12-week intervention combining nutritional education, physical activity 3 times per week and psychological supports.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* being aged 12-16 years old
* no contraindication to physical exercise
* no cardiovascular disease
* BMI above the 97th percentile
* candidate to a weight loss intervention

Exclusion Criteria

* surgery and medical conditions preventing them to perform the intervention
* Weight loss during the previous 6 months
* medication that could interfere with energy metabolism.
* pregnancy
* regular tobacco and alcool use

Minimum Eligible Age

12 Years

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No