High Doses Vitamin C and Tissular Repair in Surgical Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-15

Study Completion Date

2021-03-03

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a prospective, randomize, double-blind, and placebo-controlled study to evaluate in patients with clinical criteria for any of the following open surgical procedure: (1) cesarean section; (2) aesthetic surgery like abdominoplasty; (3) orthopedic surgery; and (4) abdominal open surgery \[excluding laparoscopic procedures\] will be invited to receive either a high dose of vitamin C (12.5 g) three times (48 h pre-surgery, immediately before surgery and 48 h post-surgery) or its placebo, to evaluate the tissue repair process using an international validated instrument named Patient and Observer Scar Assessment Scale.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Use of 2-octyl-cyanoacrylate Together With a Self-adhering Mesh

NCT01658163

Surgical Wound Dehiscence Cutis Laxa Wound of Skin

COMPLETED

Wound Healing Abnormalities in Major Abdominal Surgery

NCT00735579

Impaired Wound Healing Factor XIII Deficiency

COMPLETED

Investigation of Oxidative Stress in Appendectomy - Open Versus Laparoscopic in Childhood and Adolescence

NCT03723642

Appendicitis Acute

UNKNOWN NA

Prophylaxis of Surgical Wound Infection With Topical Antibiotics

NCT04476212

Surgical Site Infection Surgery--Complications Colorectal Surgery +2 more

UNKNOWN NA

Antiseptic-Coated Sutures and Pancreatic Fistula Risk After Pancreatoduodenectomy

NCT07318493

Pancreatoduodenectomy Whipple Procedure

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Tissue Damage

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Vitamin C

i.v. infusion of 12.5 g vitamin C 48 h before surgery, immediately before surgery, and 48 h after surgery

Group Type EXPERIMENTAL

Vitamin C

Intervention Type DIETARY_SUPPLEMENT

12.5 grams of ascorbic acid

Control

i.v. infusion of placebo 48 h before surgery, immediately before surgery, and 48 h after surgery

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

vehicle

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Vitamin C

12.5 grams of ascorbic acid

Intervention Type DIETARY_SUPPLEMENT

Placebo

vehicle

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Older than 18 years.
* Susceptible for any of the following surgical procedures: (1) cesarean section; (2) aesthetic abdominal plastic surgery; (3) orthopedic prosthetic replacement surgery
* Voluntary consent to participate