Understand the Association Between Peritoneal Dialysis Status and Gene Polymorphisms of VEGF and KDR

NCT ID: NCT04888065

Last Updated: 2021-05-17

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-05-10
• Study Completion Date: 2020-12-30

Brief Summary

Peritoneal dialysis (PD) is an effective and successful way of renal replacement therapy. The initial transport status is related to distribution of blood vessels and micro inflammation state in peritoneum before PD. Vascular endothelial growth factor(VEGF) and its receptor, kinase insert domain containing receptor(KDR) may play important roles on initial transport status.

This study include 200 PD patients from Renji Hospital in Shanghai, China. According to the 4h D/P Cr within three months of starting PD therapy, we analyzed the association between the polymorphisms of VEGF and KDR and initial peritoneal transport property.

Conditions

Peritoneal Dialysis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Patients are Han Chinese;

2. Patients prepare for dialysis in our center, and start PD within 3 months after abdominal catheterization;

3. Patients successfully complete the first peritoneal equilibration test(PET);

4. Follow up regularly in our PD center.

Exclusion Criteria

1. Patients from hemodialysis to peritoneal dialysis;

2. Patients who need peritoneal dialysis due to transplant-renal loss;

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

RenJi Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

YUE QIAN, MD

Role: PRINCIPAL_INVESTIGATOR

RenJi Hospital

Locations

Renji Hospital

Shanghai, Shanghai Municipality, China

Countries

China

References

Qian Y, Ding L, Cao L, Yu Z, Shao X, Wang L, Zhang M, Wang Q, Che X, Jiang N, Yan H, Fang W, Jin Y, Huang J, Gu A, Ni Z. Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis. BMC Nephrol. 2022 Nov 14;23(1):365. doi: 10.1186/s12882-022-02975-5.

Reference Type: DERIVED

PMID: 36376833 (View on PubMed)

Other Identifiers

2018-220

Identifier Type: -

Identifier Source: org_study_id