Prospective Evaluation of Topical Almond Oil vs Hydroquinone
NCT ID: NCT04875715
Last Updated: 2025-09-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE4
50 participants
INTERVENTIONAL
2021-07-01
2026-08-01
Brief Summary
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Detailed Description
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There will be a total of 50 subjects:
* 25 randomized to receive almond oil nightly
* 25 randomized to receive 2% hydroquinone nightly
Study Timelines:
* The duration of an individual subject's participation will last from the day of the consent/screening (visit 1) until visit 5 where they will have images taken and measurements collected to assess skin pigment, skin hydration, sebum excretion rate.
* The duration of participation is 4 months.
* The estimated time for the investigators to complete primary analysis is 2 years.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Almond oil
Almond Oil Pressed Cold
Almond Oil
Almond oil
Hydroquinone
Hydroquinone 2% cream
Hydroquinone Topical
Hydroquinone 2% cream
Interventions
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Almond Oil
Almond oil
Hydroquinone Topical
Hydroquinone 2% cream
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Smoking is an independent risk factor and serves as a confounder for the development of facial aging \[18\]. Therefore current smokers, those that have smoked within the past year, and former smokers with greater than a 20 pack year history of smoking will be excluded.
* Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndrome) will be excluded as this can be a confounder for facial photoaging.
* Hormonal medications or therapies will not be allowed unless they have been stable on their medications for at least 2 months. Examples include oral contraceptives, progesterone-based injections, and estrogen based hormonal replacement therapy.
* Those who have undergone any cosmetic procedures to the face in the 4 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment will also not be eligible.
* Individuals who are unwilling to discontinue vitamin E containing supplements and food sources during the washout and intervention.
* Individual who are unwilling to discontinue topical cosmetic products during the duration of the study.
* Individuals who are not willing to engage in a two-week washout on topical treatments known to affect facial pigmentation and these agents will be restricted during the study period as well. These include topicals that contain:
* Retinoids such as tretinoin, adapalene, retinol.
* Antioxidant ingredients such as vitamin C or vitamin E.
* Pigment-reducing agents such as hydroquinone, azelaic acid, kojic acid per the discretion of the investigator except for the hydroquinone that is provided in this study.
* Topicals that contain a nut oil or nut extract as part of their ingredient list.
* Furthermore, subjects will be asked to refrain from use of any other topical products for one week prior to each visit apart from the study agents supplied from this study.
18 Years
FEMALE
No
Sponsors
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University of California, Davis
OTHER
Responsible Party
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Principal Investigators
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Raja Sivamani, MD MS AP
Role: PRINCIPAL_INVESTIGATOR
UC Davis Dermatology
Locations
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UC Davis Department of Dermatology, Clinical Trials Unit
Sacramento, California, United States
Countries
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Central Contacts
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Facility Contacts
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Related Links
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Learn more or sign up for the study here!
Other Identifiers
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1666478
Identifier Type: -
Identifier Source: org_study_id
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