Efficacy and Safety of TAF for 48 Weeks in HBeAg Positive CHB Patients

NCT ID: NCT04864366

Last Updated: 2023-03-15

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-04-30
• Study Completion Date: 2023-12-31

Brief Summary

The objective of this clinical study was to observe the changes of HBsAg levels after a sequential 48 weeks-treatment of TAF in ETV experienced CHB patients and to monitor the levels of cytokines such as IFN-λ3, IP-10, IL-12, IL-10, and IL-21.

Detailed Description

The first-line NAs include entecavir (ETV), tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF). All the NAs mentioned above could achieve complete virologic response. NAs mentioned above are sufficient in inhibiting viral replication. However, there may exist difference in long-term prognosis such as HBsAg level decline, resistance development and HCC development. A prospective study performed by our team previously showed that TDF was better than ETV in HBsAg decline. A Korean research showed that TDF therapy was associated with a significantly lower risk of HCC than ETV therapy; the TDF group showed a distinct reduction in HBsAg level after one-year treatment. Also, a Japanese RCT study indicated that the reduction in HBsAg level was significantly greater in the TDF arm than the ETV arm at week 24. The mechanism of HBsAg decline induced by TDF has not been fully elucidated. Patients treated with nucleotide analogues (adefovir, tenofovir) had higher serum IFN-λ3 levels than those treated with nucleoside analogues (lamivudine, entecavir), according to results recently published in Gut. A team from Japan has found that nucleotide analogues inhibit LPS-mediated IL-10 production and induce IL-12p70 and TNF-α production. We speculated that, compared with entecavir, tenofovir could up-regulate IFN-λ3 and reduce the level of HBsAg more significantly.

As known as the second generation of TDF, TAF has a significantly longer half-life than TDF. A phase 3 study displayed that TAF 25 mg was non-inferior to TDF 300 mg in suppressing HBV replication, with a better performance in renal and bone safety. However, there is lack of study evaluating TAF in reducing HBsAg and induces IFN-λ3.The aim of this study was to investigate whether the TAF can achieve a better antiviral therapeutic endpoint, i.e. a greater reduction in HBsAg levels, or even meet the therapeutic expectation of stopping NAS in a larger number of treated patients.

The objective of this clinical study was to observe the changes of HBsAg levels after a sequential 48 weeks-treatment of TAF in ETV experienced CHB patients and to monitor the levels of cytokines such as IFN-λ3, IP-10, IL-12, IL-10, and IL-21.

Conditions

Chronic Hepatitis B

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Treatment naive patients

1. HBV DNA> 20000 IU/ml

2. ALT>2×ULN；or ALT>1×ULN，but liver biopsy showed inflammation greater than or equal to G2, or/and liver fibrosis greater than or equal to S2

3. No treatment with NA or/or αIFN within 1 year

Tenofovir Alafenamide 25 MG [Vemlidy]

Intervention Type: DRUG

TAF is administered as a 25mg/tablet, taken orally with food once daily, for 48 weeks.

ETV treatment experienced patients

1. ETV treatment for 1 to 2 years before

2. HBsAg>3000IU/mL

3. HBV DNA<20IU/mL

4. ALT<1×ULN

5. No other NA therapy prior to entecavir treatment

6. Patients had a desire to convert to TAF therapy

Tenofovir Alafenamide 25 MG [Vemlidy]

Intervention Type: DRUG

TAF is administered as a 25mg/tablet, taken orally with food once daily, for 48 weeks.

Interventions

Tenofovir Alafenamide 25 MG [Vemlidy]

TAF is administered as a 25mg/tablet, taken orally with food once daily, for 48 weeks.

Intervention Type: DRUG

Eligibility Criteria

Exclusion Criteria

Treatment naive patients

• treated with NA or/or αIFN within 1 year
• Pregnant women, lactating women, or women who plan to become pregnant within 2 years
• Co-infection with Hepatitis C, Hepatitis D or HIV;
• Chronic liver diseases with non-HBV etiology (including but not limited to: autoimmune hepatitis, primary biliary cirrhosis, primary cirrhosis cholangitis, hemochromatosis, etc.
• There is evidence of Child-Pugh grade C decompensated liver disease, or moderate to severe ascites, and grade III-IV hepatic encephalopathy
• There are symptoms and signs of hepatocellular carcinoma. If screening for alpha-fetoprotein (AFP) <50 ng / mL, imaging examination are not required; but if screening for AFP> 50 ng / mL, imaging examination are required
• current alcohol or drug abuse may affect compliance
• Patients who recieved solid organ or bone marrow transplantation. Liver or kidney transplantation patients can be enrolled
• malignant tumors within 5 years. Patients being evaluated for possible malignant tumors should be excluded
• Study drugs were used within 3 months prior to screening
• Patients who are participating in other clinical trials, or have been treated with the study drugs within 12 weeks before screening
• Inability or unwillingness to provide informed consent or non-compliance with research requirements
• Patients who are unwilling to purchase TAF on their own

ETV treatment experienced patients

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Huashan Hospital

OTHER

Sponsor Role: lead

Responsible Party

Jiming Zhang

chief physician,professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jiming Zhang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Huashan Hospital

Locations

Huashan Hospital Affiliated to Fudan University

Shanghai, , China

Ruijin Hospital Affiliate to Shanghai Jiao Tong University School of Medicine

Shanghai, , China

Shanghai Public Health Clinical Center

Shanghai, , China

Countries

China

Other Identifiers

TAF-HBeAg-CHB

Identifier Type: -

Identifier Source: org_study_id