SAPIEN 3 Ultra EU PMS

NCT ID: NCT04860752

Last Updated: 2025-07-29

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-20

Study Completion Date

2024-07-22

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will evaluate real-world outcomes for the SAPIEN 3 Ultra Transcatheter Heart Valve System in transcatheter aortic valve implantation centres that are implementing minimalist periprocedural practices and facilitating early discharge home.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a prospective, observational, single-arm, multicentre, post-market study.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aortic Stenosis Aortic Valve Stenosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Transcatheter Aortic Valve Implantation (TAVI)

Subjects will undergo TAVI

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Will undergo TAVI with the Edwards SAPIEN 3 Ultra System
2. Less than 80 years of age at time of the procedure
3. Low surgical risk
4. Meets clinical and procedural requirements for early discharge
5. The subject or subject's legal representative has been informed of the nature of the study, agrees to its provisions and has provided written informed consent

Exclusion Criteria

1. Medical, social, or psychological conditions that preclude appropriate consent and follow-up, including subjects under guardianship
2. Considered to be part of a vulnerable population
3. Active SARS-CoV-2 infection (Coronavirus-19 \[COVID-19\]) or previously diagnosed with COVID-19 with sequelae that could confound endpoint assessments
4. Cannot tolerate an anticoagulation/antiplatelet regimen
5. Active bacterial endocarditis
6. Participating in a drug or device study that has not reached its primary endpoint
Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Edwards Lifesciences

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

LKH-Univ. Graz Klinik, Auenbruggerplaz 15

Graz, , Austria

Site Status

Universitaetsklinikum St. Poelten, Klinik fuer Innere Medizin 3

Sankt Pölten, , Austria

Site Status

Medizinische Universitaet Vienna

Vienna, , Austria

Site Status

Helsinki University Hospital

Helsinki, , Finland

Site Status

Tampere University Hospital, Teiskontie 35

Tampere, , Finland

Site Status

Clinique St Augustin

Bordeaux, , France

Site Status

Institut Hospitalier Jacques Cartier Massy

Massy, , France

Site Status

CHU Bordeaux Hôpital Haut-Lévêque

Pessac, , France

Site Status

CHU Hopital Charles Nicolle Rouen

Rouen, , France

Site Status

Hdz Bad Oeynhausen

Bad Oeynhausen, , Germany

Site Status

Deutches Herzzentrum Berlin

Berlin, , Germany

Site Status

Universitäres Herz- und Gefäßzentrum UKE Hamburg

Hamburg, , Germany

Site Status

UKSH University Hospital Kiel

Kiel, , Germany

Site Status

Hospital Universitaet Mainz

Mainz, , Germany

Site Status

Deutsches Herzzentrum Muenchen

München, , Germany

Site Status

LMU, Klinikum der Universitaet Meunchen - Großhadern

München, , Germany

Site Status

Ospedale Moscati, Contrada Amoretta

Avellino, , Italy

Site Status

Azienda Ospedaliera Universitaria Federico II

Napoli, , Italy

Site Status

Irccs Ismett

Palermo, , Italy

Site Status

Ospedale San Camillo

Roma, , Italy

Site Status

Ospedale Santissima Annunziata

Sassari, , Italy

Site Status

Ospedale Mauriziano

Torino, , Italy

Site Status

Azienda ULSS2 Marca Trevigiana

Treviso, , Italy

Site Status

Ospedale Civile Maggiore

Verona, , Italy

Site Status

Oslo Universitetssykehus Rikshospitalet

Oslo, , Norway

Site Status

Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Estrada do Forte do Alto do Duque

Lisbon, , Portugal

Site Status

Hospital Santa Maria

Lisbon, , Portugal

Site Status

Centro Hospitalar de Vila Nova de Gaia

Vila Nova de Gaia, , Portugal

Site Status

Complexo Hospitalario Universitario Coruna

A Coruña, , Spain

Site Status

Hospital Universitario Clínico San Carlos

Madrid, , Spain

Site Status

Hospital Clinico Universitario Virgen de la Arrixaca

Murcia, , Spain

Site Status

Hospital Universitario Valdecilla Santander, Av. de Valdecilla 25

Santander, , Spain

Site Status

Hospital Alvara Cunqueiro, Estrada de Clara Campoamor 341

Vigo, , Spain

Site Status

Universitatsspital Zurich

Zurich, , Switzerland

Site Status

Leeds General Infirmary

Leeds, , United Kingdom

Site Status

St Thomas' Hospital

London, , United Kingdom

Site Status

Oxford John Radcliffe Hospital

Oxford, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Austria Finland France Germany Italy Norway Portugal Spain Switzerland United Kingdom

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2020-02

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Edwards SAPIEN 3 PPI Registry
NCT03497611 COMPLETED
SOURCE XT REGISTRY
NCT01238497 COMPLETED
FlexNav EU CE Mark Study
NCT03724812 COMPLETED NA