Fat Absorption and Metabolism After Roux-en-Y Gastric Bypass
NCT ID: NCT04859816
Last Updated: 2022-08-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
24 participants
INTERVENTIONAL
2021-04-01
2022-05-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Roux-en-Y gastric bypass operated participants
Roux-en-Y gastric bypass operated participants in weight stable phase \> 1 year from surgery
Metabolic test
Iv and oral administration of stable isotope tracers during fasting and a high-fat liquid mixed meal
DXA-scan
Dual energy X-ray Absorptiometry scan of whole-body fat
MRS
Magnetic resonance spectroscopy of liver fat content
Feces collection
4-day feces collection
Control participants
Age, sex, and BMI-matched un-operated participants.
Metabolic test
Iv and oral administration of stable isotope tracers during fasting and a high-fat liquid mixed meal
DXA-scan
Dual energy X-ray Absorptiometry scan of whole-body fat
MRS
Magnetic resonance spectroscopy of liver fat content
Feces collection
4-day feces collection
Interventions
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Metabolic test
Iv and oral administration of stable isotope tracers during fasting and a high-fat liquid mixed meal
DXA-scan
Dual energy X-ray Absorptiometry scan of whole-body fat
MRS
Magnetic resonance spectroscopy of liver fat content
Feces collection
4-day feces collection
Eligibility Criteria
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Inclusion Criteria
* RYGB \> 12 months prior to inclusion
* Weight stable (± 3 kg during the last month)
* HbA1c \< 48 mmol/mol before surgery, and no history of diabetes
* HbA1c \< 48 mmol/mol and fasting plasma glucose \< 6.1 mmol/l at inclusion
* Age \> 18 years
* No former bariatric surgery
* Weight stable (± 3 kg during the last month)
* HbA1c \< 48 mmol/mol, fasting plasma glucose \< 6.1, and no history of diabetes
Exclusion Criteria
* Haemoglobin \< 6.5 mmol/l at inclusion
* Pregnancy (pregnancy test in fertile woman before enrolment) or breast feeding
* Medication affecting the planned examinations which cannot be paused during the study period.
* Adherence to extreme diets with excessively high or low contributions from certain macronutrients (e.g. ketogenic diet)
* Complications restricting eating behavior (e.g. postprandial hypoglycemia, vomiting or strictures)
* MR contraindications
18 Years
75 Years
ALL
Yes
Sponsors
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Hvidovre University Hospital
OTHER
Responsible Party
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Morten Gadegaard Hindsø, MD
Principal Investigator
Locations
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Hvidovre Hospital
Hvidovre, , Denmark
Countries
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Other Identifiers
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FAT-BAR
Identifier Type: -
Identifier Source: org_study_id
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