TRanscriptomic Analysis of Circulating Endothelial Cells During Sepsis - TRACES Study

NCT ID: NCT04841824

Last Updated: 2021-04-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-30

Study Completion Date

2026-08-31

Brief Summary

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Vascular dysfunction is an important mechanism involved in organ failure, in the setting of sepsis condition, with different types of circulating endothelial cells.Transcriptom analysis via RNAseq in different types of circulating endothelial cells, comapring critically ill patients with or without sepsis will allow determining differential gene expression for signal pathways in endothelial alteration and restoration associated with sepsis.

Detailed Description

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Conditions

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Critical Illness With or Without Sepsis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Critically ill patients with sepsis

Observational study

Intervention Type OTHER

Observational study. Groups are defined based on baseline patients' characteristics : presence or absence of sepsis.

Critically ill patients without sepsis

No interventions assigned to this group

Interventions

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Observational study

Observational study. Groups are defined based on baseline patients' characteristics : presence or absence of sepsis.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age between 18 and 85 years
* Admission in intensive care with or without sepsis
* Health insurance as per the national insurance system
* Informed and unopposed patient for participation (or referend closed one)

Exclusion Criteria

* Patient under legal protection
* Patient under national medical help system
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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AP-HP Hôpital Saint Louis

Paris, , France

Site Status

Countries

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France

Central Contacts

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Lara Zafrani, MD PhD

Role: CONTACT

+33 1 42 49 94 19

Facility Contacts

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Lara Zafrani, MD PhD

Role: primary

Other Identifiers

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APHP201060

Identifier Type: -

Identifier Source: org_study_id

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