A Study of Replagal in Treatment-naïve Adults With Fabry Disease

NCT ID: NCT04840667

Last Updated: 2024-06-17

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE3
• Total Enrollment: 17 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-12-28
• Study Completion Date: 2022-12-16

Brief Summary

In this study, adults with Fabry Disease who have not had any treatment for this condition will be treated with Replagal. The main aim of the study is to check if Replagal improves kidney function and heart structure of participants with Fabry Disease. Participants will receive one Replagal infusion every other week for up to 104 weeks. They will visit the clinic every 12 to 14 weeks during treatment with a follow-up visit 2 weeks after treatment.

Conditions

Fabry Disease

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

REPLAGAL

Participants will receive REPLAGAL 0.2 milligram per kilogram (mg/kg) body weight of intravenous (IV) infusion Every Other Week (EOW) for 104 weeks.

Group Type: EXPERIMENTAL

REPLAGAL

Intervention Type: DRUG

Participants will receive REPLAGAL 0.2 mg/kg body weight of IV infusion for 104 weeks.

Interventions

REPLAGAL

Participants will receive REPLAGAL 0.2 mg/kg body weight of IV infusion for 104 weeks.

Intervention Type: DRUG

Other Intervention Names

SHP675

Eligibility Criteria

Inclusion Criteria

• The participant must voluntarily sign an Institutional Review Board (IRB)/Independent Ethics Committee/Research Ethics Board approved informed consent form after all relevant aspects of the study have been explained and discussed with the participant.
• The participant has Fabry disease as confirmed at screening by the following criteria using a dried blood spot (DBS) assay:

1. For male participants, Fabry disease is confirmed by a deficiency of alpha-galactosidase A (GLA) activity and a mutation in the GLA gene

2. For female participants, Fabry disease is confirmed by a mutation in the GLA gene

• The participant is 18 to 65 years of age, inclusive.
• Female participants must have a negative pregnancy test at screening.
• Female participants of child-bearing potential must agree to use a medically acceptable method of contraception at all times during the study and for at least 14 days after the final study infusion; the methods of acceptable contraception are listed in the protocol.
• The participant is deemed, as determined by the investigator, to have adequate general health to undergo the specified protocol-related procedures and to have no safety or medical contraindications for participation.
• The participant has not received any treatment (approved or investigational) specific to Fabry disease, such as enzyme replacement therapy (ERT), chaperone therapy, or substrate reduction therapy.
• The participant must have an eGFR of 45 to 120 milliliter per minute per 1.73 square meter (mL/min/1.73 m^2); eGFR will be calculated by a Shire-designated laboratory using the CKD-EPI formula. If the eGFR measurement at screening is not within the range, a second eGFR measurement may be completed and, if in range, used as the screening value. If a second measurement is taken, a minimum of 1 week and maximum of 30 days should separate it from the first. This inclusion criterion follows the European Guidelines for Treatment of Fabry Disease and Kidney Disease Improving Global Outcomes guidelines for classification of renal disease.
• The participant has left ventricular hypertrophy (LVH), where LVH is defined as left ventricular mass index (LVMI) greater than (>) 50 gram per square meter (g/m^2.7) confirmed by cardiac magnetic resonance imaging (cMRI) at screening. The cMRI value at screening will serve as the baseline value.

Exclusion Criteria

• In the opinion of the investigator, the participant's life expectancy is less than or equal to (<=) 5 years.
• The participant has undergone or is scheduled to undergo kidney transplantation or is currently on dialysis, or has any signs or symptoms of end stage renal disease.
• Urine protein/creatinine ratio (PCR) greater than (>) 1.5 milligram per milligram (mg/mg).
• Participants who have clinically relevant history of allergy or signs or symptoms of severe hypersensitivity, (including hypersensitivity to the REPLAGAL active substance or any of the excipients), which in the investigator's judgment, will substantially increase the participant's risk if he or she participates in the study.
• Cardiac fibrosis involving more than 2 segments, as determined by cMRI at screening.
• In the opinion of the investigator, the participant has non-Fabry disease-related cause of end-organ (renal, cardiac, central nervous system) dysfunction/failure or is receiving medications that may affect the rate of disease progression, as assessed by cardiac and/or renal measures.
• The participant has a positive test at screening for hepatitis B surface antigen, positive test for hepatitis B core antibody, positive test for hepatitis C (HCV) antibody with confirmation by HCV-ribonucleic acid polymerase chain reaction testing, or positive test for human immunodeficiency virus antibody.
• Treatment with REPLAGAL at any time prior to the study.
• Prior treatment with any of the following medications:

1. FABRAZYME (agalsidase beta) and its biosimilars

2. GLYSET (miglitol)

3. ZAVESCA (miglustat)

4. CERDELGA (eliglustat)

5. GALAFOLD (migalastat)

6. Any investigational product for treatment of Fabry disease

• Treatment at any time during the study with the following medications:

1. Chloroquine

2. Amiodarone

3. Monobenzone

4. Gentamicin

• The participant is pregnant or lactating.
• The participant has a body mass index > 39 kilogram per square meter (kg/ m^2). (Body mass index [BMI] = kg/ m^2).
• The participant is treated or has been treated with any investigational drug within 30 days of study start.
• The participant is unable to understand the nature, scope, and possible consequences of the study.
• The participant is unable to comply with the protocol, eg, uncooperative with protocol schedule, refusal to agree to all of the study procedures, inability to return for evaluations, or is otherwise unlikely to complete the study, as determined by the investigator.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shire

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Study Director

Role: STUDY_DIRECTOR

Shire

Locations

M.A.G.I.C. Clinic Ltd. Metabolics and Genetics in Calgary

Calgary, , Canada

Queen Elizabeth II Health Sciences Center

Halifax, , Canada

Turun Yliopistollinen Keskussairaala

Turku, , Finland

Vaasan Keskussairaala

Vaasa, , Finland

Charité - Universitätsklinikum

Berlin, , Germany

SphinCS

Höchheim, , Germany

Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Mainz, , Germany

Fachinternistische Gemeinschaftspraxis

Müllheim, , Germany

Universitaetsklinikum Wuerzburg

Würzburg, , Germany

Laiko General Hospital of Athens

Athens, , Greece

Attikon University General Hospital

Athens, , Greece

University General Hospital of Heraklion

Heraklion, , Greece

University Hospital of Ioannina

Ioannina, , Greece

Onasseio Private Practise Hospital of Piraeus

Kallithea, , Greece

Papageorgiou General Hospital of Thessaloniki

Thessaloniki, , Greece

Szpital Uniwersytecki

Krakow, , Poland

Narodowy Instytut Kardiologii im Prymasa Tysiaclecia Kardynala Stefana Wyszynskiego - Instytut Badaw

Warsaw, , Poland

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu

Wroclaw, , Poland

Centro Hospitalar e Universitário de Coimbra EPE

Coimbra, , Portugal

Hospital Senhora da Oliveira - Guimaraes, E.P.E

Guimarães, , Portugal

Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria

Lisbon, , Portugal

Hospital General Universitario de Alicante

Alicante, , Spain

Hospital de Torrecárdenas

Almería, , Spain

Hospital Universitario Vall d'Hebrón - PPDS

Barcelona, , Spain

Hospital Universitario La Paz

Madrid, , Spain

Hospital Universitario Virgen del Rocio - PPDS

Seville, , Spain

Hospital Quironsalud Zaragoza

Zaragoza, , Spain

Akademiska Sjukhuset I Uppsala

Uppsala, , Sweden

Countries

Canada; Finland; Germany; Greece; Poland; Portugal; Spain; Sweden

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Related Links

https://clinicaltrials.takeda.com/study-detail/61147ce4cd353f0032b92064

To obtain more information on the study, click here/on this link

Other Identifiers

2018-004689-32

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

SHP675-301

Identifier Type: -

Identifier Source: org_study_id