The Effect of the Rubber Hand Illusion on Sensory Thresholds

NCT ID: NCT04837443

Last Updated: 2021-07-27

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-05-28
• Study Completion Date: 2021-10-01

Brief Summary

The rubber hand illusion (RHI) causes a change in body perception and awareness as a result of the integration of simultaneously perceived visual and tactile stimulation. In the rubber hand illusion (RHI), which was first described in 1998, a realistic hand model is perceived as a part of the body and body awareness is impaired. In the RHI, the participant's real hand is positioned behind a screen so that it is out of sight; The rubber model hand is placed in the field of vision and in the appropriate position with the real hand. Brush is applied simultaneously to the same parts of the real and rubber hands. He/she perceives the rubber hand as his own and the brush starts to feel as if it is being rubbed into his own hand. This method, which causes the illusion of body belonging, has been defined as the rubber hand illusion. During the rubber hand illusion, increased activity was observed in the ventral premotor cortex, infraparietal cortex and cerebellum in functional MRI. It is suggested that this phenomenon occurs with the integration of interrelated visual, tactile and proprioceptive senses reaching the premotor cortex.

Quantitative sensory tests are standardized subjective clinical sensitivity tests that require the collaboration of the person to be examined. In the tests, calibrated stimuli are applied to capture perception and pain thresholds, thus providing information about sensory thresholds.

The impairment of body perception caused by RHI contributes to the multi-faceted understanding of sensory perception, higher-level cognitive processes, brain mapping and functions. In the studies; It has been suggested that the conflict between visual and proprioceptive sensory information created during the rubber hand illusion is resolved by the attenuation of somatosensory input at the cortical level.

As far as we know, tactile sensory threshold from quantitative sensory tests, two-point discrimination from cortical senses, pressure pain threshold measured by the algometer, and vibration threshold variation during and after rubber hand burning, which causes changes in body perception, have not been studied before. In this study, the relationship between the RHI phenomenon and sensory thresholds will be evaluated.

Conditions

Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: DOUBLE

Study Groups

Synchronous working group

Group Type: EXPERIMENTAL

Rubber hand illusion

Intervention Type: BEHAVIORAL

Tactile sensory threshold from quantitative sensory tests, two point discrimination from cortical senses, pressure pain threshold measured by algometer will be examined during and after the rubber hand burning, which causes changes in body perception.

Asynchronous working group

Group Type: SHAM_COMPARATOR

Rubber hand illusion

Intervention Type: BEHAVIORAL

Tactile sensory threshold from quantitative sensory tests, two point discrimination from cortical senses, pressure pain threshold measured by algometer will be examined during and after the rubber hand burning, which causes changes in body perception.

Interventions

Rubber hand illusion

Tactile sensory threshold from quantitative sensory tests, two point discrimination from cortical senses, pressure pain threshold measured by algometer will be examined during and after the rubber hand burning, which causes changes in body perception.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Healthy
• 18-65 years old age

Exclusion Criteria

• Neuropathy
• Presence of any known neurological or psychiatric disease
• Inability to cooperate with the tests to be performed
• Amputation and nerve damage in the upper extremities
• Upper extremities dysfunction due to nerve damage

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Gazi University

OTHER

Sponsor Role: lead

Responsible Party

Zafer Günendi

professor doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Gazi University Faculty of Medicine Department of PMR

Ankara, , Turkey (Türkiye)

Site Status: RECRUITING

Countries

Turkey (Türkiye)

Central Contacts

zafer günendi, MD

Role: CONTACT

zafergunendi@yahoo.com

+903122025219

Facility Contacts

hatice ceylan, MD

Role: primary

+903122025219

References

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Reference Type: BACKGROUND

PMID: 16343947 (View on PubMed)

Botvinick M, Cohen J. Rubber hands 'feel' touch that eyes see. Nature. 1998 Feb 19;391(6669):756. doi: 10.1038/35784. No abstract available.

Reference Type: BACKGROUND

PMID: 9486643 (View on PubMed)

Ramakonar H, Franz EA, Lind CR. The rubber hand illusion and its application to clinical neuroscience. J Clin Neurosci. 2011 Dec;18(12):1596-601. doi: 10.1016/j.jocn.2011.05.008. Epub 2011 Oct 13.

Reference Type: BACKGROUND

PMID: 22000838 (View on PubMed)

Mohan R, Jensen KB, Petkova VI, Dey A, Barnsley N, Ingvar M, McAuley JH, Moseley GL, Ehrsson HH. No pain relief with the rubber hand illusion. PLoS One. 2012;7(12):e52400. doi: 10.1371/journal.pone.0052400. Epub 2012 Dec 20.

Reference Type: BACKGROUND

PMID: 23285026 (View on PubMed)

Fang W, Zhang R, Zhao Y, Wang L, Zhou YD. Attenuation of Pain Perception Induced by the Rubber Hand Illusion. Front Neurosci. 2019 Mar 22;13:261. doi: 10.3389/fnins.2019.00261. eCollection 2019.

Reference Type: BACKGROUND

PMID: 30967758 (View on PubMed)

Fischer AA. Pressure algometry over normal muscles. Standard values, validity and reproducibility of pressure threshold. Pain. 1987 Jul;30(1):115-126. doi: 10.1016/0304-3959(87)90089-3.

Reference Type: BACKGROUND

PMID: 3614975 (View on PubMed)

Won SY, Kim HK, Kim ME, Kim KS. Two-point discrimination values vary depending on test site, sex and test modality in the orofacial region: a preliminary study. J Appl Oral Sci. 2017 Jul-Aug;25(4):427-435. doi: 10.1590/1678-7757-2016-0462.

Reference Type: BACKGROUND

PMID: 28877282 (View on PubMed)

Haloua MH, Sierevelt I, Theuvenet WJ. Semmes-weinstein monofilaments: influence of temperature, humidity, and age. J Hand Surg Am. 2011 Jul;36(7):1191-6. doi: 10.1016/j.jhsa.2011.04.009.

Reference Type: BACKGROUND

PMID: 21712138 (View on PubMed)

Other Identifiers

217

Identifier Type: -

Identifier Source: org_study_id