Influence of Prematurity and Its Respiratory Sequel on Exercise Testing in Childhood

NCT ID: NCT04833647

Last Updated: 2021-04-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

83 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-04-01

Study Completion Date

2021-02-01

Brief Summary

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Prospective study comparing hemodynamic and respiratory changes and exercise capacity during Cardio-Pulmonary-Exercise-Testing (CPET) in 4 groups of infants; Three different groups of premature infants and term controls

Detailed Description

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The study population included 4 groups of infants; preterm infants born \< 300 weeks' gestation with BPD (i.e. oxygen dependence for at least 28 postnatal days 5), preterm infants born \< 300 weeks' gestation without BPD, late preterm infants (born at 340-366 weeks' gestation) and term controls.

Pulmonary function testing and spirometry were measured Participants performed CPET on an electronically braked cycle ergometer. During the exercise testing, serial saturation, heart rate and blood pressure measurements were obtained.

The peak oxygen consumption (VO2max) was measured and served as the primary endpoint of the study.

Conditions

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The Peak Oxygen Consumption (VO2max) Was Measured and Served as the Primary Endpoint of the Study

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Participants performed CPET on an electronically braked cycle ergometer . During the exercise testing, serial saturation, heart rate and blood pressure measurements were obtained. The peak oxygen consumption (VO2max) was measured and served as the primary endpoint of the study. A CPET technician and a senior pediatrician were present and monitored the participants' condition during the study.
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Term

7-10 years old born at 37-42 weeks gestation

Group Type OTHER

Cardio-Pulmonary-Exercise-Testing (CPET)

Intervention Type DIAGNOSTIC_TEST

Cardio-Pulmonary-Exercise-Testing (CPET) . During the exercise testing, serial saturation, heart rate and blood pressure measurements were obtained. The peak oxygen consumption (VO2max) was measured and served as the primary endpoint of the study

Late preterms

7-10 years old born at 34.0-36.6 weeks gestation

Group Type OTHER

Cardio-Pulmonary-Exercise-Testing (CPET)

Intervention Type DIAGNOSTIC_TEST

Cardio-Pulmonary-Exercise-Testing (CPET) . During the exercise testing, serial saturation, heart rate and blood pressure measurements were obtained. The peak oxygen consumption (VO2max) was measured and served as the primary endpoint of the study

Preterms with BPD

7-10 years old born before 30 weeks gestation with the diagnosis of BPD: the need for oxygen at 36 weeks gestation and/or flow or 3LPM or more, and/or the need for CPAP or invasive ventilation

Group Type OTHER

Cardio-Pulmonary-Exercise-Testing (CPET)

Intervention Type DIAGNOSTIC_TEST

Cardio-Pulmonary-Exercise-Testing (CPET) . During the exercise testing, serial saturation, heart rate and blood pressure measurements were obtained. The peak oxygen consumption (VO2max) was measured and served as the primary endpoint of the study

pretermas without BPD

7-10 years old born before 30 weeks gestation without the diagnosis of BPD (without the need for oxygen at 36 weeks gestation and/or flow or 3LPM or more, and/or the need for CPAP or invasive ventilation)

Group Type OTHER

Cardio-Pulmonary-Exercise-Testing (CPET)

Intervention Type DIAGNOSTIC_TEST

Cardio-Pulmonary-Exercise-Testing (CPET) . During the exercise testing, serial saturation, heart rate and blood pressure measurements were obtained. The peak oxygen consumption (VO2max) was measured and served as the primary endpoint of the study

Interventions

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Cardio-Pulmonary-Exercise-Testing (CPET)

Cardio-Pulmonary-Exercise-Testing (CPET) . During the exercise testing, serial saturation, heart rate and blood pressure measurements were obtained. The peak oxygen consumption (VO2max) was measured and served as the primary endpoint of the study

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* 7-10 years of age
* The ability to ride stationary bicycles as assessed by the parents.

Exclusion Criteria

* Immobility
* An acute febrile or upper respiratory illness in the last 2 weeks
* The use systemic or inhaled steroids or antiepileptic drugs in the previous month
* Inhaled bronchodilator use in the previous 24 hours
* A chronic lung illness (with the exception of BPD and asthma)
* Congenital cardiac defect (with the exception of atrial septal defect and patent foramen ovale).
Minimum Eligible Age

7 Years

Maximum Eligible Age

10 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Rambam Health Care Campus

OTHER

Sponsor Role lead

Responsible Party

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Ori Hochwald , MD

Director, NICU

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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0239-14-RMB

Identifier Type: -

Identifier Source: org_study_id

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