A Study to Investigate the Effect of Food on the PK, PD of CKD-381 in Healthy Volunteers

NCT ID: NCT04830930

Last Updated: 2021-08-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-04-21

Study Completion Date

2021-07-26

Brief Summary

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A study to investigate the effect of food on the Pharmacokinetics and pharmacodynamics of CKD-381 in healthy volunteers

Detailed Description

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A randomized, open-label, single-dose, crossover study to investigate the effect of food on the pharmacokinetics and pharmacodynamics of CKD-381 in healthy volunteers

Conditions

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GERD

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Crossover Assignment
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Sequence 1

Period 1: fasted condition/ Period 2: fed condition

Group Type EXPERIMENTAL

CKD-381

Intervention Type DRUG

single-dose, oral administration of CKD-381 1 tablet

Sequence 2

Period 1: fed condition/ Period 2: fasted condition

Group Type EXPERIMENTAL

CKD-381

Intervention Type DRUG

single-dose, oral administration of CKD-381 1 tablet

Interventions

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CKD-381

single-dose, oral administration of CKD-381 1 tablet

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Between 19 aged and 50 aged in healthy adult
2. Body weight more than 55.0kg and body mass index over 18.0kg/m2 and under 30.0kg/m2
3. Have negative result on Helicobacter Pylori antibody test

Exclusion Criteria

1. Have clinically significant disease that hepatobiliary system, kidney, nervous system, immune system, respiratory system, endocrine system, hemato-oncology disease, cardiovascular system or mental illness, or a history of mental disease.
2. Have a gastrointestinal disease history(including surgery) that can effect evaluation of safety, pharmacokinetics and pharmacodynamics of investigational product.
3. Hypersensitivity reaction or clinically significant hypersensitivity reaction in the history of investigational product, additives or benzimidazole family.
Minimum Eligible Age

19 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chong Kun Dang Pharmaceutical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kyungsang Yu, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

[email protected]

Locations

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Seoul National University Hospital

Seoul, Jongno-gu, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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A73_04FDI2102

Identifier Type: -

Identifier Source: org_study_id

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