DPP4 Inhibitor and Coronary Atherosclerosis in Patients Receiving Insulin Therapy

NCT ID: NCT04825795

Last Updated: 2023-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

4007 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-01

Study Completion Date

2021-03-30

Brief Summary

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The study aim is to evaluate whether DPP4-inhibitor could reduce coronary atherosclerosis assessed by CT scan in patients receiving insulin for diabetes mellitus. In this retrospective study, changes in obstructive coronary artery disease prevalence and coronary calcium burden between two coronary CT scans will be compared in patients with and without receiving DPP4-inhibitor.

Detailed Description

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This is a retrospective study using medical records in two hospitals affiliated to the Catholic University of Korea. Patients with diabetes mellitus who received insulin are retrospectively enrolled. Among those, only patients who underwent coronary CT scan for more than two times will be included. Included patients will be classified into DPP4-inhibitor group and no DPP4-inhibitor group according to the prescribed medication. The changes in obstructive coronary artery disease prevalence and coronary calcium score per one year will be compared between the two groups.

Conditions

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Diabetes Mellitus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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DPP4-inhibitor

Patients who were prescribed DPP4-inhibitor during the period between two coronary CT scan.

DPP4-inhibitor

Intervention Type DRUG

Prescription of DPP4-inhibitor during the period between the two coronary CT scan

No DPP4-inhibitor

Patients who were not prescribed DPP4-inhibitor during the period between two coronary CT scan.

No DPP4-inhibitor

Intervention Type DRUG

No prescription of DPP4-inhibitor during the period between the two coronary CT scan

Interventions

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DPP4-inhibitor

Prescription of DPP4-inhibitor during the period between the two coronary CT scan

Intervention Type DRUG

No DPP4-inhibitor

No prescription of DPP4-inhibitor during the period between the two coronary CT scan

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diabetes mellitus
* Receiving chronic insulin therapy (prescription of insulin pen)
* Who underwent more than 2 times of coronary CT scan

Exclusion Criteria

* Age \<18
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Catholic University of Korea

OTHER

Sponsor Role lead

Responsible Party

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Sang Hyun Ihm, MD PhD

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sang-Hyun Ihm, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea

Locations

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Bucheon St. Mary's Hospital

Bucheon-si, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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XC21WIDI0044

Identifier Type: -

Identifier Source: org_study_id

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