Liver Transplantation for Unresectable GIST Liver Metastases

NCT ID: NCT04825470

Last Updated: 2022-03-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-31

Study Completion Date

2025-12-31

Brief Summary

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Liver Transplantation for Unresectable GIST Liver Metastases

Detailed Description

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Conditions

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Liver Diseases Liver Cancer Liver Metastases Liver Neoplasms Liver Mass Liver Carcinoma Liver Transplant; Complications Liver Transplant Disorder GIST GIST, Malignant Gastrointestinal Stromal Tumors Gastrointestinal Stromal Tumor of Duodenum Gastrointestinal Stromal Tumor of Rectum Gastrointestinal Stromal Tumor of Other Sites Gastrointestinal Stromal Tumor, Unspecified Site Gastrointestinal Stromal Tumor of Stomach Gastrointestinal Stromal Tumor of Esophagus (Disorder) Gastrointestinal Stromal Tumor by AJCC V8 Stage Gastrointestinal Stromal Tumor, Malignant Gastrointestinal Stromal Tumor (GIST) of the Gastrointestinal Tract Gastrointestinal Stromal Tumor of Small Intestine (Disorder) Gastrointestinal Stromal Tumor of Large Intestine (Disorder) Metastases to Liver Metastatic Liver Cancer Metastasis Metastases Liver Transplantation Transplant Oncology

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Liver Transplantation

Group Type EXPERIMENTAL

Liver Transplantation

Intervention Type PROCEDURE

Liver Transplantation

Interventions

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Liver Transplantation

Liver Transplantation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* GIST diagnosis (c-Kit, CD34, DOG-1)
* Imatinib-sensitive mutation
* Non-resectable liver metastases
* Abscence of extrahepatic disease
* Period greater than two years between primary tumor and metastases diagnosis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Universitario Virgen de la Arrixaca

OTHER

Sponsor Role lead

Responsible Party

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Felipe Alconchel

MD, PhD, Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Felipe Alconchel

Murcia, , Spain

Site Status

Countries

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Spain

Facility Contacts

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Felipe Alconchel, MD, PhD

Role: primary

+34667524352

References

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Fernandez JA, Alconchel F, Gomez B, Martinez J, Ramirez P. Unresectable GIST liver metastases and liver transplantation: A review and theoretical basis for a new indication. Int J Surg. 2021 Oct;94:106126. doi: 10.1016/j.ijsu.2021.106126. Epub 2021 Sep 27.

Reference Type BACKGROUND
PMID: 34592432 (View on PubMed)

Related Links

Other Identifiers

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TRANSGIST

Identifier Type: -

Identifier Source: org_study_id

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