Weight Reduction in CLBP

NCT ID: NCT04824248

Last Updated: 2025-05-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-01

Study Completion Date

2026-12-01

Brief Summary

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We will recruit overweight/ obese participants between the age of 18 and 65 with chronic nonspecific low back pain . The participants will be randomly assigned to one of two interventions (each lasting 10 weeks). All interventions will be delivered in a blended format and will be a combination of online education material and face-to-face sessions with a physical therapist. The first group (experimental intervention) will receive a behavioral weight reduction program combined with pain neuroscience education plus cognition-targeted exercise therapy. Participants in the second group (control intervention) will receive pain neuroscience education and cognition-targeted exercise therapy alone. Allocation to the groups will be at random. Participants and assessors will be blinded for group allocation. The primary outcomes is pain intensity. Secondary outcomes include other pain related outcomes, body composition, physical activity, sedentary behavior, dietary intake and function.

Detailed Description

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Conditions

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Chronic Low-back Pain Overweight or Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized controlled clinical trial, including two comparative, balanced online treatment arms.
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Experimental intervention

10 weeks blended therapy delivered using a blended approach. The blended (online and on site) therapy consists of instructive video's, challenges to complete, 1-on-1 sessions with the therapist, online quizzes, online booklets, and online diaries/workbooks. . The experimental group will receive a behavioral weight reduction program combined with pain neuroscience education plus cognition-targeted exercise therapy. The combined therapy will adhere to guidelines for patient-centered care

Group Type EXPERIMENTAL

Pain Neuroscience Education

Intervention Type BEHAVIORAL

Increase pain coping skills and educating the patients that pain is in the brain, and that hypersensitivity of the central nervous system rather than local tissue damage contributes to their symptoms.

Cognition-targeted exercise therapy

Intervention Type BEHAVIORAL

Daily (physical) activity and exercise therapy. To confront the patient with movements and activities that are feared, avoided and/or painful using a gradual and cognition-targeted approach.

Behavioral weight reduction program

Intervention Type BEHAVIORAL

Changes in diet, behavior and a physical exercise to reach weight loss. It will include a lifestyle approach, incorporating behavioral theories and constructs to assist and facilitate healthy energy balance related behavior.

Control intervention

Identically to the experimental intervention, the therapy is provided in a blended format within 10 weeks. Also identical to the experimental intervention, the control intervention will adhere to guidelines for patient-centered care. The control group will receive pain neuroscience education in combination with cognition-targeted exercise therapy alone.

Group Type ACTIVE_COMPARATOR

Pain Neuroscience Education

Intervention Type BEHAVIORAL

Increase pain coping skills and educating the patients that pain is in the brain, and that hypersensitivity of the central nervous system rather than local tissue damage contributes to their symptoms.

Cognition-targeted exercise therapy

Intervention Type BEHAVIORAL

Daily (physical) activity and exercise therapy. To confront the patient with movements and activities that are feared, avoided and/or painful using a gradual and cognition-targeted approach.

Interventions

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Pain Neuroscience Education

Increase pain coping skills and educating the patients that pain is in the brain, and that hypersensitivity of the central nervous system rather than local tissue damage contributes to their symptoms.

Intervention Type BEHAVIORAL

Cognition-targeted exercise therapy

Daily (physical) activity and exercise therapy. To confront the patient with movements and activities that are feared, avoided and/or painful using a gradual and cognition-targeted approach.

Intervention Type BEHAVIORAL

Behavioral weight reduction program

Changes in diet, behavior and a physical exercise to reach weight loss. It will include a lifestyle approach, incorporating behavioral theories and constructs to assist and facilitate healthy energy balance related behavior.

Intervention Type BEHAVIORAL

Other Intervention Names

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Pain Education

Eligibility Criteria

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Inclusion Criteria

* Overweight (BMI ≥ 25 kg/m2) or obese (BMI ≥ 30 kg/m2) with chronic low back pain
* Non-specific low back pain for at least 3 months' duration
* Currently seeking care for low back pain
* Native Dutch speaker
* Access to internet and computer/tablet/smartphone

Exclusion Criteria

* Leg pain of 7 or higher (on a maximum of 10) on a numeric rating scale
* Evidence of specific spinal pathology (e.g., hernia, spinal stenosis, spondylolisthesis, infection, spinal fracture or malignancy)
* Evidence of a severe underlying comorbidity (e.g. diabetes, cardiovascular problems, metabolic diseases)
* BMI ≥ 40 kg/m2
* Being pregnant or given birth in the preceding year
* Currently receiving dietary or exercise interventions
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rotterdam University of Applied Sciences

OTHER

Sponsor Role collaborator

Vrije Universiteit Brussel

OTHER

Sponsor Role lead

Responsible Party

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Malfliet Anneleen

Prof. Dr. Anneleen Malfiet

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Vrije Universiteit Brussel

Brussels, , Belgium

Site Status RECRUITING

Rotterdam University of Applied Sciences

Rotterdam, , Netherlands

Site Status RECRUITING

Countries

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Belgium Netherlands

Central Contacts

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Anneleen Malfliet, PhD

Role: CONTACT

003224774503

Facility Contacts

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Anneleen Malfliet, PhD

Role: primary

Lennard Voogt, PhD

Role: primary

Other Identifiers

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B.U.N. 1432021000411

Identifier Type: -

Identifier Source: org_study_id

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