Impact of Von Willebrand Factor and Its Multimers on Angiogenesis

NCT ID: NCT04810702

Last Updated: 2024-03-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-02-07

Study Completion Date

2024-08-07

Brief Summary

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The study aims to study the expression of numerous proteins involved in angiogenesis in 70 patients with von Willebrand disease in order to try to identify markers of interest. Secondly, the investigators plan to investigate whether there is a relationship between the proteins tested, the distribution of multimers and the clinical phenotype of the patients, in particular by looking for the presence of bleeding linked to the presence of angiodysplasias.

Detailed Description

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Conditions

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Von Willebrand Diseases

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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patients with von Willebrand disease

no intervention

Intervention Type OTHER

no intervention

case control

no intervention

Intervention Type OTHER

no intervention

Interventions

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no intervention

no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

For patients:

* Patient with von Willebrand disease proven by genetic analysis of the VWF gene.
* Lack of treatment that could interfere with angiogenesis.
* Patient informed by an information note sent to his home, with the possibility of objecting to the use of his blood samples in the context of research.

For the control:

* Patient with a normal coagulation report
* Absence of abnormal hemorrhagic symptoms
* Lack of notion of angiodysplasia.
* Lack of treatment that could interfere with angiogenesis.
* Patient informed by an information note sent to his home, with the possibility of objecting to the use of his blood samples in the context of research.

Exclusion Criteria

* Patient under guardianship or curatorship.
* Pregnant and lactating women.
* Blood transfusion or treatment with von Willebrand factor concentrates less than 7 days old.
* Treatment which may interfere with angiogenesis.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Nantes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU de Nantes

Nantes, , France

Site Status RECRUITING

Countries

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France

Facility Contacts

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Marc Fouassier

Role: primary

0240084049

Other Identifiers

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RC20_0531

Identifier Type: -

Identifier Source: org_study_id

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