A Study of CDPATH™ to Help Manage and Treat Crohn's Disease

NCT ID: NCT04809363

Last Updated: 2025-11-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE4

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-25

Study Completion Date

2026-09-12

Brief Summary

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CDPATH™ is a tool to help predict the potential for developing Crohn's disease related complications in certain adult participants within 3 years. The main aim of the study is to explore the use of CDPATH™ to describe a participant's risk profile and to have discussions with their doctor about the potential path of their Crohn's disease. The number of visits will be decided by the study clinic according to their standard practice.

Detailed Description

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The tool being tested in this study is called CDPATH™. CDPATH™ is being used to provide a graphical representation of an individual participant's risk of developing a CD-related complication within three years, leveraging known participant risk factors based on clinical, serologic and genetic variables to help people categorize risk who have CD. This study will gather data on the use of the tool in real-world settings to inform practical use of CDPATH™.

The study will enroll approximately 200 patients. Participants and health care providers (HCPs) will be surveyed to understand their satisfaction with the CDPATH™ process and with their treatment choice.

This multi-center trial will be conducted in the United States. The overall time to participate in this study is 36 months. Participants will make multiple visits to the HCP's clinic, and data will be collected approximately every six months up to 3 years, based on the timing of routine follow-up appointments for assessment.

Conditions

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Crohn's Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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CDPATH™

Participants with CD will be using CDPATH™ tool. Clinical data will be collected via an ongoing registry. Participants and health care provider (HCP)-reported outcomes data will be collected periodically once every 6 months for up to 36 months via electronic surveys. Two baseline blood samples will be collected at screening for CDPATH™ analysis. 1 additional sample will be collected for future potential biomarker analysis.

Group Type EXPERIMENTAL

CDPATH™

Intervention Type OTHER

Crohn's disease risk prediction tool.

Blood Draw

Intervention Type OTHER

Three blood samples will be drawn.

Interventions

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CDPATH™

Crohn's disease risk prediction tool.

Intervention Type OTHER

Blood Draw

Three blood samples will be drawn.

Intervention Type OTHER

Other Intervention Names

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PROSPECT

Eligibility Criteria

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Inclusion Criteria

1. Has an initial diagnosis of CD established within five years prior to screening by clinical and endoscopic evidence and corroborated by a histopathology report (if available).
2. Has agreed to use the CDPATH™ tool.
3. Has reliable access to the internet and is willing to answer electronic patient-reported outcomes (ePROs) throughout the study.

Exclusion Criteria

1. Has had known complications from CD including but not limited to: bowel stricture, CD-related intra-abdominal abscess, internal penetrating disease (known fistula other than perianal fistula), non-perianal surgery, bowel resection, or stricturoplasty. A perianal fistula or abscess without other signs of penetrating disease is allowed.
2. Has had any non-CD-related abdominal surgery.
3. Has received investigational biologic or nonbiologic agents for the treatment of CD in an investigational protocol. Approved biologic or nonbiologic agents for CD are allowed.
4. Has previously used CDPATH™ or PROSPECT results to assess CD risk for complications.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Takeda

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Study Director

Role: STUDY_DIRECTOR

Takeda

Locations

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Arizona Arthritis & Rheumatology Research, PLLC

Phoenix, Arizona, United States

Site Status

VA Loma Linda Healthcare System

Loma Linda, California, United States

Site Status

United Medical Doctors

Murrieta, California, United States

Site Status

University of Southern California Medical Center

Newport Beach, California, United States

Site Status

Clinnova Research Solutions

Orange, California, United States

Site Status

University of California at Irvine Medical Center

Orange, California, United States

Site Status

Kaiser Permanate of Colorado

Aurora, Colorado, United States

Site Status

Medical Research Center of Connecticut, LLC

Hamden, Connecticut, United States

Site Status

West Central Gastroenterology d/b/a Gastro Florida

Clearwater, Florida, United States

Site Status

Gastroenterology Associates of Pensacola, PA

Pensacola, Florida, United States

Site Status

Grand Teton Research Group, PLL

Idaho Falls, Idaho, United States

Site Status

GI Alliance

Arlington Heights, Illinois, United States

Site Status

GI Alliance

Gurnee, Illinois, United States

Site Status

Comprehensive Gastrointestinal Health

Northbrook, Illinois, United States

Site Status

Rockford Gastroenterology Associates, Ltd.

Rockford, Illinois, United States

Site Status

Indiana University

Indianapolis, Indiana, United States

Site Status

Iowa Digestive Disease Center

Clive, Iowa, United States

Site Status

University of Iowa Hospitals & Clinics

Iowa City, Iowa, United States

Site Status

University of Kansas Medical Center Research Institute, Inc.

Kansas City, Kansas, United States

Site Status

GI Alliance - Baton Rouge

Baton Rouge, Louisiana, United States

Site Status

Louisiana Research Center, LLC

Shreveport, Louisiana, United States

Site Status

Gastro Center of Maryland

Columbia, Maryland, United States

Site Status

Lahey Clinic Inc. - PARENT ACCOUNT

Burlington, Massachusetts, United States

Site Status

UMASS Memorial Medical Center

Worcester, Massachusetts, United States

Site Status

University of New Mexico

Albuquerque, New Mexico, United States

Site Status

Lenox Hill Hospital

New York, New York, United States

Site Status

Clinical Inquest Center Ltd

Beavercreek, Ohio, United States

Site Status

Dayton Gastroenterology, Inc

Dayton, Ohio, United States

Site Status

The Oregon Clinic, P.C.

Portland, Oregon, United States

Site Status

Susquehanna Research Group, LLC

Camp Hill, Pennsylvania, United States

Site Status

Allegheny Center for Digestive Health

Pittsburgh, Pennsylvania, United States

Site Status

University of Pittsburgh Medical Center Health System

Pittsburgh, Pennsylvania, United States

Site Status

Frontier Clinical Research, LLC

Uniontown, Pennsylvania, United States

Site Status

Palmetto Primary Care Physician Division of Gastroenterology

Summerville, South Carolina, United States

Site Status

Rapid City Medical Center, LLC

Rapid City, South Dakota, United States

Site Status

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Site Status

The University of Texas at Austin

Austin, Texas, United States

Site Status

Baylor College of Medicine

Houston, Texas, United States

Site Status

GI Alliance - Southlake

Southlake, Texas, United States

Site Status

Care Access Research Berkley

Ogden, Utah, United States

Site Status

University of Utah

Salt Lake City, Utah, United States

Site Status

GCGA Physicians LLC

Fairfax, Virginia, United States

Site Status

Gastroenterology Associates

Lynchburg, Virginia, United States

Site Status

GI Alliance

Bellevue, Washington, United States

Site Status

Countries

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United States

Related Links

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https://clinicaltrials.takeda.com/study-detail/605cd65feb9d7e001f5bc6a2

Click here for more information about this trial in easy-to-understand language, including a Plain Language Summary of the results if the trial has been completed.

Other Identifiers

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Vedolizumab-4015

Identifier Type: -

Identifier Source: org_study_id

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