Follow-up to Welcome Study C87042 [NCT00308581] Examining Certolizumab Pegol (CDP870) in Subjects With Crohn's Disease

NCT ID: NCT00333788

Last Updated: 2018-08-07

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

233 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2010-04-30

Brief Summary

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The study will continue to assess the safety of certolizumab pegol (CDP870) as well as examine the evolution of long term efficacy in Crohn's disease patients who completed study C87042 \[NCT00308581\]. It will also assess the effect of subcutaneous CDP870 400 mg on direct cost parameters.

Detailed Description

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Conditions

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Crohn's Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Certolizumab pegol 400 mg

400 mg subcutaneous injection of certolizumab pegol every 2 (Q2W) or 4 (Q4W) weeks

Group Type EXPERIMENTAL

Certolizumab pegol (CDP870)

Intervention Type BIOLOGICAL

400 mg subcutaneous (sc) injection of Certolizumab pegol (CDP870) every 2 (Q2W) or 4 (Q4W) weeks

Interventions

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Certolizumab pegol (CDP870)

400 mg subcutaneous (sc) injection of Certolizumab pegol (CDP870) every 2 (Q2W) or 4 (Q4W) weeks

Intervention Type BIOLOGICAL

Other Intervention Names

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CDP870 Cimzia

Eligibility Criteria

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Inclusion Criteria

* Patients having completed study C87042 \[NCT00308581\] (previously treated with infliximab)

Exclusion Criteria

* Subject withdraw from C87042 \[NCT00308581\] study
* Subject who received treatment other than certolizumab pegol and other than medications permitted in C87042 \[NCT00308581\] study
* Subjects from countries where certolizumab pegol is authorized in Crohn's disease treatment
* Female patients of childbearing age who are NOT practicing (in the Investigator's opinion) effective birth control. All female patients must test negative on a serum pregnancy test before study entry and negative on urine testing immediately before every certolizumab pegol administration
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UCB Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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UCB Clinical Trial Call Center

Role: STUDY_DIRECTOR

+1 877 822 9493 (UCB)

Locations

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Gainesville, Florida, United States

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Atlanta, Georgia, United States

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Chicago, Illinois, United States

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Indianapolis, Indiana, United States

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Louisville, Kentucky, United States

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Baton Rouge, Louisiana, United States

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Lincoln, Nebraska, United States

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New York, New York, United States

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Chapel Hill, North Carolina, United States

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Charleston, North Carolina, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Portland, Oregon, United States

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Charleston, South Carolina, United States

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Germantown, Tennessee, United States

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Nashville, Tennessee, United States

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Houston, Texas, United States

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Seattle, Washington, United States

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Innsbruck, , Austria

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Vienna, , Austria

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Bonheiden, , Belgium

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Brussels, , Belgium

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Genk, , Belgium

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Ghent, , Belgium

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Leuven, , Belgium

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Liège, , Belgium

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Roeselare, , Belgium

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Edmonton, Alberta, Canada

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Vancouver, British Columbia, Canada

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London, Ontario, Canada

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Toronto, Ontario, Canada

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Calgary, , Canada

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Clichy, , France

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Lille, , France

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Nice, , France

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Paris, , France

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Pessac, , France

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Berlin, , Germany

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Hamburg, , Germany

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Herne, , Germany

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Kiel, , Germany

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Leipzig, , Germany

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Minden, , Germany

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Munich, , Germany

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München, , Germany

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Bologna, , Italy

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Milan, , Italy

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Padua, , Italy

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Palermo, , Italy

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Roma, , Italy

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Torino, , Italy

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Eindhoven, , Netherlands

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Heerlen, , Netherlands

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Barcelona, , Spain

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Madrid, , Spain

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Santiago de Compostela, , Spain

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Seville, , Spain

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Valencia, , Spain

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Stockholm, , Sweden

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Bern, , Switzerland

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Lausanne, , Switzerland

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Bristol, , United Kingdom

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London, , United Kingdom

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Oxford, , United Kingdom

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Countries

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United States Austria Belgium Canada France Germany Italy Netherlands Spain Sweden Switzerland United Kingdom

Related Links

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Other Identifiers

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2006-001729-24

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

C87046

Identifier Type: -

Identifier Source: org_study_id

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