Understanding Fabry Disease Therapy Choices Through the Eyes of the Patients

NCT ID: NCT04804566

Last Updated: 2024-04-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

44 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-01

Study Completion Date

2023-11-01

Brief Summary

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The objective of this study is to increase the understanding surrounding the choices presented to patients and families impacted by Fabry disease.

Detailed Description

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This will be a cross-sectional study conducted in approximately 130 individuals (or representative parents/caregivers of patients) living with Fabry disease. All study participants will complete the RSVP followed by a structured interview conducted by trained interviewers. It is estimated that each respondent will need up to 60 minutes for the entire process; 10 minutes to complete the RSVP including uploading the proof of Fabry disease diagnosis or verifying membership with Fabry groups, including but not limited to: Fabry Support and Information Group, National Fabry Disease Foundation, MPS Society UK, Morbus Fabry Selbsthilfergruppe, Fabry International Network, or others, and approximately 50 minutes to complete the interview.

Conditions

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Fabry Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ERT User- Did Not Switch to Galafold

ERT users with mutation amenable to Galafold who did not switch

This is a non-interventional study

Intervention Type OTHER

This is a non-interventional study

ERT User- Switched and Stayed on Galafold

ERT users with the mutation amenable to Galafold who switched and stayed on Galafold

This is a non-interventional study

Intervention Type OTHER

This is a non-interventional study

No Previous Therapy- Started Galafold and Stayed On

Those naïve to therapy with the mutation amenable to Galafold who went on and stayed on Galafold

This is a non-interventional study

Intervention Type OTHER

This is a non-interventional study

No Previous Therapy- No Current Therapy

Those who were naïve to therapy with the mutation amenable to Galafold and have never been on any therapy.

This is a non-interventional study

Intervention Type OTHER

This is a non-interventional study

ERT Users- Switched and Discontinued Galafold

Participants who are ERT users with an amenable mutation who switched to and later discontinued Galafold

This is a non-interventional study

Intervention Type OTHER

This is a non-interventional study

No Previous Therapy- Started Galafold and Discontinued

Participants who are naïve to therapy with an amenable mutation, went on Galafold, and discontinued

This is a non-interventional study

Intervention Type OTHER

This is a non-interventional study

Interventions

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This is a non-interventional study

This is a non-interventional study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Participant must be a person with Fabry disease who is 18 years or older or the parent/legal guardian of a living person with Fabry disease who is under the age of 18 years or who are 18 years and older who are unable to answer for themselves.
* Confirmed diagnosis of Fabry disease with written proof of disease provided
* Must have a genetic mutation that is amenable to oral therapy
* Resident of Germany, the U.K or the U.S.
* Able to read, write and communicate in German, or English.
* Able to grant informed consent
* Willing to participate in a 50 to 60-minute telephone interview, including follow up questions (if necessary) and information regarding adverse events (if necessary).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Engage Health Inc.

INDUSTRY

Sponsor Role collaborator

Amicus Therapeutics

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Niloofar Nobakht, MD

Role: PRINCIPAL_INVESTIGATOR

Ronald Regan UCLA Medical Center

Locations

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Engage Health

Eagan, Minnesota, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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AT-NIS-00002

Identifier Type: -

Identifier Source: org_study_id

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