Enzyme Activity of Matrix Metalloproteinases in the Serum of Patients With Malignant Obstructive Hyperbilirubinemia Before and After PTBD

NCT ID: NCT04801914

Last Updated: 2021-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-11

Study Completion Date

2021-05-11

Brief Summary

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The purpose of this study is to detect differences in the enzymatic activity of matrix metalloproteinases in patients with malignant obstructive hyperbilirubinemia before and after percutaneous biliary drainage.

Detailed Description

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This study will be designed as a prospective cohort study involving the collection of peripheral blood samples before and one month after percutaneous biliary drainage for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity). Biochemical analyzes are preceded by the entry of data relevant to the research (demographic, anamnestic, clinical and biochemical).

Conditions

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Matrix Metalloproteinase

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Matrix Metalloproteinases

Value of serum matrix metalloproteinase activity before and one month after PTBD

Percutaneous biliary drainage

Intervention Type PROCEDURE

Collection of peripheral blood samples before and one month after percutaneous biliary drainage performed for patients with malignant obstructive hyperbilirubinemia for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity).

Interventions

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Percutaneous biliary drainage

Collection of peripheral blood samples before and one month after percutaneous biliary drainage performed for patients with malignant obstructive hyperbilirubinemia for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity).

Intervention Type PROCEDURE

Other Intervention Names

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Matrix Metalloproteinase serum activity measurement

Eligibility Criteria

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Inclusion Criteria

pathological confirmation or imaging data confirming malignant disease causing bile duct obstruction, performance status 0-1

Exclusion Criteria

terminally ill patients, performance status \>2, hepatic decompensation, severe underlying cardiac or renal diseases and coagulation disorders.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Klinički centar Srbije

UNKNOWN

Sponsor Role collaborator

Institut za Rehabilitaciju Sokobanjska Beograd

OTHER

Sponsor Role lead

Responsible Party

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Tamara Filipovic

Phd

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kristina Gopcevic, Phd

Role: STUDY_DIRECTOR

Institute for chemistry in medicine, Medical school, University of Belgrade

Locations

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University Clinical Center of Serbia

Belgrade, , Serbia

Site Status RECRUITING

Countries

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Serbia

Central Contacts

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Aleksandar N Filipovic, Dr

Role: CONTACT

+381658832505

Facility Contacts

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Aleksandar N Filipovic, Dr

Role: primary

+381658832505

Other Identifiers

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717/11

Identifier Type: -

Identifier Source: org_study_id

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