Optimal Duration of Oxaliplatin in Adjuvant XELOX for Gastric Cancer Patients (EXODOX)

NCT ID: NCT04787354

Last Updated: 2022-02-21

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 976 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-11-01
• Study Completion Date: 2027-12-31

Brief Summary

This study aims to compare the efficacy and safety of reduced adjuvant XELOX treatment (4 cycles of XELOX followed by 4 cycles of capecitabine alone) to standard adjuvant XELOX treatment (8 cycles of XELOX).

Detailed Description

XELOX (oxaliplatin + capecitabine) combination chemotherapy is considered a standard adjuvant treatment for curatively resected gastric cancer patients after it proved its effecacy in the CLASSIC trial. Adjuvant XELOX chemotherapy is a long-term treatment with a total treatment period of 6 months and it is known that about 33% of patients cannot complete treatment schedule due to side effects. In particular, peripheral neuropathy, which is caused by the cumulative administration of oxaliplatin, is a major cause of lowering the patient's quality of life and treatment compliance, and it is known that the incidence rate increases when standard XELOX treatment is continued for more than 6 cycles. In colorectal cancer, clinical studies have been actively conducted to shorten the duration of standard adjuvant chemotherapy to reduce the peripheral sensory neuropathy caused by oxaliplatin, but there are no relevant studies in gastric cancer.

This study aims to compare the efficacy and safety of reduced adjuvant XELOX treatment (4 cycles of XELOX followed by 4 cycles of capecitabine alone) to standard adjuvant XELOX treatment (8 cycles of XELOX).

Conditions

Gastric Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Control arm

Standard adjuvant XELOX 8 cycles

Oxaliplatin: 130 mg/m2/day(day 1) Capecitabine: 2,000 mg/m2/day(day 1-14), q 3weeks, total 8 cycles

Group Type: ACTIVE_COMPARATOR

Oxaliplatin

Intervention Type: DRUG

Oxaliplatin: 130 mg/m2/day

Capecitabine

Intervention Type: DRUG

Capecitabine: 2,000 mg/m2/day

Study arm

Adjuvant XELOX 4 cycles followed by capecitabine monotherapy 4 cycles

Oxaliplatin: 130 mg/m2/day(day 1) Capecitabine: 2,000 mg/m2/day(day 1-14), q 3weeks, 4 cycles

followed by

Capecitabine: 2,000 mg/m2/day(day 1-14), q 3weeks, 4 cycles

Group Type: EXPERIMENTAL

Oxaliplatin

Intervention Type: DRUG

Oxaliplatin: 130 mg/m2/day

Capecitabine

Intervention Type: DRUG

Capecitabine: 2,000 mg/m2/day

Interventions

Oxaliplatin

Oxaliplatin: 130 mg/m2/day

Intervention Type: DRUG

Capecitabine

Capecitabine: 2,000 mg/m2/day

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Histologically or cytologically confirmed gastric or gastroesophageal junction adenocarcinoma patients who underwent curative surgery (D1 beta or D2 resection)
• Pathologically confirmed stage II, III patients (AJCC 8th edition)
• Age 19 years and older
• Eastern Cooperative Oncology Group (ECOG) performance status 0 or 2
• Adequate marrow function (ANC > 1,500/uL, Platelet >100,000/uL, Hb > 8.0 g/dL, patients with chronic anemia who require intermittent blood transfusions can also participate in the study)
• Adequate renal function, with serum creatinine < 1.5 x upper limit of normal (ULN).
• Adequate hepatic function with serum total bilirubin ≤ 1.5 x ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x ULN
• Written, informed consent to the study

Exclusion Criteria

• Female patients who are pregnant or breast-feeding
• Positive pregnancy test at baseline (postmenopausal women should be amenorrhea for at least 12 months to be considered non-fertile)
• Sexually active men and women who are not willing to implement contraception during study and until 3 months after discontinuation of study drug
• Evidence of metastasis (including cytologically confirmed malignant ascites)
• Prior systemic chemotherapy or radiation therapy for stomach cancer
• Patients who have not recovered from serious complications of gastrectomy
• History of other malignancies within the last 3 years (excluding adequately treated basal cell carcinoma of the skin, in situ cancer of the cervix, non-metastatic thyroid cancer)
• A history of clinically significant uncontrolled seizures, central nervous system disorders, or mental disorders, which make it impossible to understand the informed consent or interfere with compliance with oral drug intake
• Clinically significant (i.e., active) heart disease: e.g. unstable angina requiring medication, symptomatic coronary artery disease, congestive heart failure with NYHA grade II or higher, severe cardiac arrhythmias or acute coronary syndrome in the past 6 months (including myocardial infarction)
• Lack of integrity or malabsorption syndrome in the upper gastrointestinal tract, which is likely to affect the absorption of study drug
• Serious uncontrolled infection or other serious uncontrolled disease
• History of allograft requiring immunosuppression therapy
• Received any investigational drug or procedure within 4 weeks prior to randomization
• Active viral infection (for hepatitis B carrier, patients can be registered if HBV-DNA titer is less than 20,000 IU/mL, and are allowed to use prophylactic antiviral agents by investigator's choice)
• Active HIV infection
• Patients with peripheral sensory neuropathy with functional impairment

• Minimum Eligible Age: 19 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hallym University Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Zang, Dae Young

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Hallym University Medical Center

Gyeonggi-do, , South Korea

Site Status: RECRUITING

Countries

South Korea

Central Contacts

Bum Jun Kim, Dr

Role: CONTACT

getwisdom1025@gmail.com

82-31-380-3704

Facility Contacts

Bum Jun Kim

Role: primary

getwisdom1025@gmail.com

82-31-380-3704

Other Identifiers

KCSG ST21-05

Identifier Type: -

Identifier Source: org_study_id