Natural History and Patient Journey in Atrial Fibrillation: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

NCT ID: NCT04786366

Last Updated: 2021-03-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

5601803 participants

Study Classification

OBSERVATIONAL

Study Start Date

1998-01-01

Study Completion Date

2021-06-30

Brief Summary

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The trajectory of atrial fibrillation (AF) patients within the national health system and their recent temporal trends remains to be fully elucidated. To study the AF incidence, mortality and case-fatality, the investigators implemented a longitudinal cohort study with the linked electronic health records of 5.6 million population in the UK from 1998 to 2016 (CALIBER). A matched case-control study design was used to investigate the causes of hospitalization and death comparing individuals with and without incident AF.

Detailed Description

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Conditions

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Atrial Fibrillation Epidemiology

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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The study does not have an intervention, but observe the AF incidence of the UK disease-free population

The study does not have an intervention, but observe the AF incidence of the UK disease-free population.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* The investigators identify individuals aged 18 years or older and registered in the current primary care practice for at least one year.

Exclusion Criteria

* Individuals are excluded if they had a prior history of AF before study entry.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University College, London

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

References

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Chung SC, Schmit AF, Lip GYH, Providencia R. Electronic health record-wide association study for atrial fibrillation in a British cohort. Front Cardiovasc Med. 2023 Sep 28;10:1204892. doi: 10.3389/fcvm.2023.1204892. eCollection 2023.

Reference Type DERIVED
PMID: 37840952 (View on PubMed)

Other Identifiers

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ISAC17_205

Identifier Type: -

Identifier Source: org_study_id

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