Study of External Neuromodulation to Improve Signs and Symptoms of Dry Eye in Visual Display Terminal Users

NCT ID: NCT04763018

Last Updated: 2021-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-17

Study Completion Date

2021-06-01

Brief Summary

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Two study arms - sham and treatment; There will be a cross over of the sham group to the treatment group at day 15.

Detailed Description

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This is a post market study. The active device will be the FDA cleared device used within its labeling. The sham group will receive an iTEAR device which looks identical to and makes noise similar to a fully functional iTEAR device but has a tip that does not vibrate. All subjects in the sham group will crossover to the treatment group after 2 two weeks and all patients will continue to 30 days.

The study will be conducted at up to 5 sites in the United States. It will enroll 30 subjects for 30 days.

This is a double-masked study with 10 subjects receiving sham and 20 subjects receiving treatment. The subjects and the examining investigators are masked to treatment until the crossover.

Conditions

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Visual Display Users With Previously Undiagnosed Dry Eye

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Day 14-30, all subjects receive therapy device
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors
Sham device produces noise but no stimulation energy. Assessor does not know which device the subject received. The subject does not know which device he or she received

Study Groups

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Treatment

This arm will receive a function iTEAR

Group Type ACTIVE_COMPARATOR

iTEAR100

Intervention Type DEVICE

Neurostimulation external nasal nerve to stimulate tear production

Sham

This arm will receive sham treatment device

Group Type SHAM_COMPARATOR

iTEAR100

Intervention Type DEVICE

Neurostimulation external nasal nerve to stimulate tear production

Interventions

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iTEAR100

Neurostimulation external nasal nerve to stimulate tear production

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* \> 6hrs visual display terminal
* OSDI \> 13
* One of: SChirmer \< 10, One quadrant staining \> 2, or Meibomian Gland expression \<12

Exclusion Criteria

* Opinion of investigator that subject not be in the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Olympic Ophthalmics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Fishman Vision

Palo Alto, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Michael gertner, MD

Role: CONTACT

650-283-9388

Other Identifiers

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CLP-OO8

Identifier Type: -

Identifier Source: org_study_id

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