Back to the Traditional: Anti-COX Drugs Can Improve the Outcome of COVID-19 Patients Admitted to ICU

NCT ID: NCT04757792

Last Updated: 2021-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

475 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-06

Study Completion Date

2021-02-11

Brief Summary

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Retrospective multicenter study to evaluate the data of COVID-19 patients who were admitted to university hospitals in relation to their recent administration or maintenance on non-steroidal anti-inflammatory drugs (NSAID) prior to have COVID-19 disease and to analyze it in relation to outcome of these patients.

Detailed Description

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The data contained in hospital registry were collected, categorized into demographic, previous medical history, the use of NSAID as maintenance therapy or its recent administration before diagnosis of COVID-19 disease, presenting manifestations, laboratory and CT findings, applied therapies or interventions. Outcomes will be categorized as survival and non-survival outcome. Survivors will be subdivided as complete recovery or recovery with getting new morbidities. Mortality was subdivided as total hospital and ICU mortality. Data will be statistically analyzed in relation to outcomes

Conditions

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COVID-19 Disease

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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No NSAID

included patients who did not receive NSAID prior to having COVID-19 disease

File inquiry

Intervention Type OTHER

Data extraction out of file registry

Apsirin

included patients who received acetylsalicylic acid (ASA) prior to having COVID-19 disease

File inquiry

Intervention Type OTHER

Data extraction out of file registry

Celecoxib

included patients who received celecoxib (CEL) prior to having COVID-19 disease

File inquiry

Intervention Type OTHER

Data extraction out of file registry

Miscellaneous

included patients who received miscellaneous NSAID other than ASA or CEL prior to having COVID-19 disease

File inquiry

Intervention Type OTHER

Data extraction out of file registry

Interventions

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File inquiry

Data extraction out of file registry

Intervention Type OTHER

Other Intervention Names

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No interventions

Eligibility Criteria

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Inclusion Criteria

* assured diagnosis of COVID-19 by RT-PCR

Exclusion Criteria

* No
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tanta University

OTHER

Sponsor Role collaborator

Cairo University

OTHER

Sponsor Role collaborator

Benha University

OTHER

Sponsor Role lead

Responsible Party

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Adel F. Alkholy

Professor of Medical Biochemistry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Adel Alkholy, Prof

Role: PRINCIPAL_INVESTIGATOR

Faculty of medicine, Banha University, Egypt

Locations

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Faculty of Medicine

Banhā, Qalyubia Governorate, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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RC1-2-2021

Identifier Type: -

Identifier Source: org_study_id

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