Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
36 participants
OBSERVATIONAL
2021-04-30
2022-03-31
Brief Summary
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The present project aims to comprehensively investigate physiological responses to altitude/hypoxia during rest and exercise in prematurely born, but otherwise healthy adults. Specifically, the investigators aim to elucidate the underlying mechanisms of the altered resting and exercise cardiovascular, respiratory, cerebral and hematological responses to hypoxia in prematurely born individuals. The obtained results from this cohort will be compared to the data from a control groups consisting of healthy, age and aerobic capacity-matched individuals born at full-term. While acute hypoxic effects will be the focus of the project's first phase, the researchers will test the effect of prolonged terrestrial (real) or simulated (normobaric hypoxia) altitude exposures in the second part. This phase will, in addition to the insight into the prolonged altitude acclimatization modulation in prematurely born individuals, also enable the potential differences between the effects of normobaric (simulated) and hypobaric (terrestrial) hypoxia in this cohort to be investigated.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Preterm born
Premature born but otherwise healthy adults exposed to normoxic, normobaric hypoxic and hypobaric hypoxic interventions.
Normoxia
48 hours experimental protocol conducted at sea level
Normobaric hypoxia
24 hours experimental protocol conducted in a normobaric hypoxic facility
Hypobaric hypoxia
72 hours experimental protocol conducted at terrestrial altitude
Full-term control
Full-term born healthy adults exposed to normoxic, normobaric hypoxic and hypobaric hypoxic interventions.
Normoxia
48 hours experimental protocol conducted at sea level
Normobaric hypoxia
24 hours experimental protocol conducted in a normobaric hypoxic facility
Hypobaric hypoxia
72 hours experimental protocol conducted at terrestrial altitude
Interventions
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Normoxia
48 hours experimental protocol conducted at sea level
Normobaric hypoxia
24 hours experimental protocol conducted in a normobaric hypoxic facility
Hypobaric hypoxia
72 hours experimental protocol conducted at terrestrial altitude
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* full-term born
* healthy individuals
* male
Exclusion Criteria
* presence of any medical condition that would make the protocol unreasonably hazardous for the patient
* smokers
* exposure to altitude above 1000m in the last 2 months
18 Years
30 Years
MALE
Yes
Sponsors
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University of Lausanne
OTHER
Jozef Stefan Institute
OTHER
Responsible Party
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Tadej Debevec
Dr.
Locations
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Jozef Stefan Institute
Ljubljana, , Slovenia
University of Ljubljana
Ljubljana, , Slovenia
Institute of Sport Sciences of the University of Lausanne
Lausanne, Canton of Vaud, Switzerland
Countries
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References
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Manferdelli G, Narang BJ, Bourdillon N, Debevec T, Millet GP. Physiological Responses to Exercise in Hypoxia in Preterm Adults: Convective and Diffusive Limitations in the O 2 Transport. Med Sci Sports Exerc. 2023 Mar 1;55(3):482-496. doi: 10.1249/MSS.0000000000003077. Epub 2022 Oct 26.
Other Identifiers
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PreAlti
Identifier Type: -
Identifier Source: org_study_id
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