Trans-arterial Chemoembolization in Patients With Hepatocellular Carcinoma: A Study of Different Outcomes and Their Predictive Factors

NCT ID: NCT04739501

Last Updated: 2021-02-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-01

Study Completion Date

2022-03-30

Brief Summary

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Radiological response after trans arterial chemoembolization (TACE) is classified according to Modified Response Evaluation Criteria in Solid Tumors (mRECIST) to: complete response (CR) (disappearance of arterial enhancement), partial response (PR) ( at least a 30% decrease in the sum of diameters of viable enhancement), progressive disease (PD) (an increase of at least 20% in the sum of the diameters of viable enhancement, or appearance of new lesions), and stable disease (any cases that do not qualify for either partial response or progressive disease

Detailed Description

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POST-TACE response of treatment for cases of hepatocellular cancer

Conditions

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Liver Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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TACE in HCC group 1

the patient did undergo tace

TACE

Intervention Type PROCEDURE

Trans-arterial chemoembolization in patients with hepatocellular carcinoma

Interventions

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TACE

Trans-arterial chemoembolization in patients with hepatocellular carcinoma

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Clinical history and examination with special stress on symptoms and signs of chronic liver disease with or without evidence of hepatic decompensation e.g. the presence of ascites and with or without evidence of complications e.g. jaundice spider naevi, bleeding varices, ascites, and lower limb edema.

Laboratory findings in the form of raised bilirubin and liver enzymes, impaired coagulation profile, and/or low serum albumin.

Abdominal ultrasonography revealing liver cirrhosis (coarse echopattern, attenuated hepatic veins, irregular outlines, hypertrophy of caudate lobe and/or shrunken liver, presence of focal hepatic) and presence of splenomegaly, ascites, or portal vein thrombosis (PVT).

Exclusion Criteria

A patient who had surgical resection or liver transplantation Patients refuse to participate Hepatic focal lesion other than HCC
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Amany Mahran Mohammed Ahmed

resident of tropical medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Assiut

Asyut, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Amany M Ahmed

Role: CONTACT

01146457697

Facility Contacts

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Amany M Mahran, Residents

Role: primary

01146457697

Other Identifiers

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0987654321

Identifier Type: -

Identifier Source: org_study_id

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