Lidocaine Versus Duloxetine for the Prevention of Taxane-Induced Peripheral Neuropathy In Breast Cancer Patients

NCT ID: NCT04732455

Last Updated: 2022-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-15

Study Completion Date

2022-07-05

Brief Summary

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The aim of the study is to evaluate the effect of intravenous (IV) lidocaine versus oral duloxetine on the onset and severity of TIPN in patient with breast cancer as well as evaluation of Patients' quality of life and estimation the cell mediated immunity.

The current study is a single blinded randomized controlled study, assumed that lidocaine could prevent and reduce TIPN similar to duloxetine in patient with breast cancer.

Method of randomization: The allocation sequence was generated using permuted block randomization technique and the block size was variable. Allocation sequence/code was concealed from the person allocating the participants to the intervention arms using sealed opaque envelopes.

Primary outcome: Degree of neuropathic pain measured by neuropathy pain scale (NPS) among breast cancer patients on Taxane chemotherapy after the pretreatment with either lidocaine or duloxetine.

Secondary outcomes are: The incidence of TIPN using DN4 questionnaire and nerve conduction study and Patients' quality of life using The European Organization for Research and Treatment of Cancer (EORTC) QLQ-CIPN20 as well as the Change in serum level natural killer cell to estimate cell mediated immunity.

Detailed Description

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Patients' assessment:

* Medical history (Previous diseases and medications)
* Clinical examination and laboratory investigations (according to patient' condition).
* Each patient will be informed with the study, its expected result and its possible side effects. The patients will be trained to use neuropathic pain scale (NPS). Additionally, DN4 questionnaire will be explained to all participants. IV line will be inserted for all participants. Vital signs including heart rate and mean arterial blood pressure will be measured.

The participants will be randomly allocated into three groups as follows:

* Group control (C): 20 adult breast cancer patients on Taxane chemo protocol will receive 200 ml normal saline over forty minutes pre each chemotherapy session until end of the cycle.
* Group lidocaine infusion (L): 20 adult breast cancer patients on Taxane chemo protocol will receive lidocaine IV infusion (2 mg/kg) in 200ml saline over forty minutes with a maximum upper limit of 200 mg pre each chemotherapy session until end of the cycle. If any selected patient reported neuropathic pain (DN4 \> 4) during the course of chemotherapy lidocaine (2 mg/kg) re-infused after each session. If lidocaine side effects such as circumoral numbness, twitches, metal test, tachy or bradycardia recorded at any time, lidocaine infusion will be reduced to 1mg/kg, if side effects persist, the patients will be managed accordingly as well as lidocaine infusion will be stopped and patient will be excluded from the study.
* Group duloxetine (D): 20 adult breast cancer patients on chemotherapy will take oral duloxetine tablet 30 mg once per day starting from the night pre chemotherapy session until the end of cycle. If any selected patient reported neuropathic pain (DN4 \> 4) during the course of chemotherapy the duloxetine dose will be adjusted to 60 mg daily till the end of the cycle. They also will receive 200 ml normal saline over forty minutes before each chemotherapy session until end of the cycle.

Measurements

Demographic features of the patients

-Age (years), Weight (kg).

Neuropathic pain characters and severity

-Intensity and characters of neuropathic pain will be measured by neuropathic pain scale (0-10cm) after each chemotherapy session which is expected to be one session every week for 12 weeks

Chemotherapy induced peripheral neuropathy

* Nerve conduction study will be performed to detect sensory peripheral neuropathy pre and immediately after the end of chemo protocol cycle.
* Detection of TIPN will be measured using DN4 questionnaire before starting chemotherapy protocol and after each chemotherapy session which is expected to be one session every week for 12 weeks

Patients' quality of life -The European Organization for Research and Treatment of Cancer (EORTC) QLQ-CIPN20 questionnaire for quality of life will be taken from patient before starting chemotherapy protocol ,one month ,two month after the treatment and at the end of treatment .

Cell mediated immunity: Natural killer cell isolation and cytotoxicity assay.

-Sample of 1ml of patients' peripheral blood will be collected on EDTA for flow cytometry to enumerate for both cytotoxic lymphocytes population (NK cells, and cytotoxic lymphocytes (ctls)). CD 56 will be used as a market for NK cells while CD8 will be used as a marker for Ctls. Cytotoxic assay will be done by measuring the release of lactate dehydrogenase (LDH) from non-viable cells (Cytotoxicity Detection kit, 630117; Clontech laboratories, Mountain View, California) according to manufacturer's instructions. Then ratio of LDH released specifically from NK cells will be carried according to the result of flow cytometry . Blood Sample will be collected at the start and the end of chemo protocol cycle of breast cancer patients.

Complications

-Any complications will occur during or after the treatment with lidocaine or duloxetine will be reported and managed accordingly.

Conditions

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Peripheral Neuropathy Chemotherapy-induced Peripheral Neuropathy Breast Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Group Control (C)

20 adult breast cancer patients on Taxane chemo protocol will receive 200 ml normal saline over forty minutes pre each chemotherapy session until end of the cycle.

Group Type PLACEBO_COMPARATOR

Normal saline

Intervention Type DRUG

200 ml normal saline over forty minutes pre each chemotherapy session until end of the cycle.

Group lidocaine infusion (L)

20 adult breast cancer patients on Taxane chemo protocol will receive lidocaine i.v infusion (2 mg/kg) in 200ml saline over forty minutes with a maximum upper limit of 200 mg pre each chemotherapy session until end of the cycle. If any selected patient reported neuropathic pain (DN4 \> 4) during the course of chemotherapy lidocaine (2 mg/kg) re-infused after each session. If lidocaine side effects such as circumoral numbness, twitches, metal test, tachy or bradycardia recorded at any time, lidocaine infusion will be reduced to 1mg/kg, if side effects persist, the patients will be managed accordingly as well as lidocaine infusion will be stopped and patient will be excluded from the study.

Group Type EXPERIMENTAL

Lidocaine in Saline

Intervention Type DRUG

Lidocaine IV infusion (2 mg/kg) in 200 ml saline over forty minutes with a maximum upper limit of 200 mg pre each chemotherapy session until end of the cycle.

Group duloxetine (D)

20 adult breast cancer patients on chemotherapy will take oral duloxetine tablet 30 mg once per day starting from the night pre chemotherapy session until the end of cycle. If any selected patient reported neuropathic pain (DN4 \> 4) during the course of chemotherapy the duloxetine dose will be adjusted to 60 mg daily till the end of the cycle. They also will receive 200 ml normal saline over forty minutes before each chemotherapy session until end of the cycle.

Group Type EXPERIMENTAL

Duloxetine 30 MG

Intervention Type DRUG

Oral Duloxetine tablet 30 mg once per day starting from the night pre chemotherapy during the whole period of chemotherapy cycle which expected to be three month

Interventions

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Lidocaine in Saline

Lidocaine IV infusion (2 mg/kg) in 200 ml saline over forty minutes with a maximum upper limit of 200 mg pre each chemotherapy session until end of the cycle.

Intervention Type DRUG

Duloxetine 30 MG

Oral Duloxetine tablet 30 mg once per day starting from the night pre chemotherapy during the whole period of chemotherapy cycle which expected to be three month

Intervention Type DRUG

Normal saline

200 ml normal saline over forty minutes pre each chemotherapy session until end of the cycle.

Intervention Type DRUG

Other Intervention Names

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L D C

Eligibility Criteria

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Inclusion Criteria

* breast cancer
* at any stage,
* Taxane chemo-protocol.

Exclusion Criteria

* Documented history of gloves and stock neuropathy.
* Alcohol abuse.
* Abnormal renal or liver function tests.
* Allergy to local anesthetics.
* Myocardial infarction within 6 months
* Profound high-grade arrhythmias.
* Patients with neurological or psychological problems.
* Diabetes Mellitus.
* History of previous chemotherapy treatment
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Gamal Mohamed Taha Abouelmagd

OTHER

Sponsor Role lead

Responsible Party

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Gamal Mohamed Taha Abouelmagd

MSc Anaesthesia and Surgical Intensive Care

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Sahar A El-Karadawy, MD

Role: STUDY_DIRECTOR

Medical Research Institute - MRI

Magda M Abo-Ollo, MD

Role: STUDY_DIRECTOR

Medical Research Institute - MRI

Wessam Z. Alamrawy, MD

Role: STUDY_DIRECTOR

Medical Research Institute - MRI

Yasmine N. Elwany, MD

Role: STUDY_DIRECTOR

Medical Research Institute - MRI

Locations

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Egypt Medical Research Institute

Alexandria, , Egypt

Site Status

Countries

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Egypt

References

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Other Identifiers

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1216-4-011

Identifier Type: -

Identifier Source: org_study_id

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