The Study of Hemp Oil CBD for Evaluation of Efficacy and Safety in Treatment of Pain, Anxiety and Insomnia Management

NCT ID: NCT04729244

Last Updated: 2021-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-01

Study Completion Date

2022-02-01

Brief Summary

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The investigators are looking to conduct a study looking at the effects of cannabidiol (CBD) from Hemp Oil in patients with Chronic pain, anxiety and insomnia. It is believed that CBD will improve pain anxiety and sleep quality and reduce opioid use. The study will last a total of 4 weeks and involve onsite visits in addition to weekly pain assessments.

Detailed Description

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The proposal is to conduct a interventional cohort pilot study to evaluate the effectiveness of CBD on the management of chronic pain, anxiety and insomnia.

Subjects will be pre-screened from new and existing patients as well as from referral sites for the diagnosis of chronic pain. Potential subjects will be screened for pain \>3 months who are using oral analgesic including narcotics and or physical therapy to reduce pain.

Those meeting all inclusion and exclusion criteria will receive a comprehensive history and physical exam and undergo informed consented at the Screening Visit. Baseline survey data will be collected including various pain rating surveys. The patient's will be monitored for compliance to complete the weekly rating using a research phone application.

Subjects will receive either CBD tincture or CBD topical cream.This will be dosed daily for a total of 4 weeks. Patients will be evaluated on three pain rating scales: On initial evaluation and 4th week evaluation, patients will be asked to fill out The Brief Pain Inventory and Pain Disability Index. Once weekly, a Numeric Rating Scale.

On initial evaluation and at 4th week evaluation, narcotic dosing will be reviewed and recorded. Quality of sleep and anxiety scale will also be recorded for the four weeks using the Hamilton Anxiety scale and Sleep Quality Assessment at the start and end of the 4 weeks. At initiation and conclusion of study blood work to evaluated levels of CBD in each patient. Subjects will be screened for side effects as well as records of pain medication use throughout the duration of the study

Conditions

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CBD Pain, Chronic Anxiety Insomnia Opioid Use

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

One group will be taking CBD tincture, the other will be using CBD cream
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CBD(hemp oil) cream

cream 2000mg/1oz (50mg/dose) once daily dosing for a total of 4 weeks to area of most pain.Patients will record outcome in pain, anxiety, sleep, and report any adverse effects.

Group Type ACTIVE_COMPARATOR

CBD

Intervention Type DRUG

Hemp Oil

CBD (Hemp oil) Tincture

1500mg CBD/30ml (50mg/dose) once daily dosing for total of 4 weeks. Patients will record outcome in pain, anxiety, sleep, and report any adverse effects.

Group Type ACTIVE_COMPARATOR

CBD

Intervention Type DRUG

Hemp Oil

Interventions

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CBD

Hemp Oil

Intervention Type DRUG

Other Intervention Names

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CBD tincture CBD cream

Eligibility Criteria

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Inclusion Criteria

* Patients with pain \>3 months who are using oral analgesic including narcotics and or physical therapy to reduce pain.
* Patient provides informed consent
* Older than 21 years old,
* Previously have used CBD or marijuana
* Speaks English

Exclusion Criteria

* Patients who are receiving interventional pain procedures or surgery within 30 days
* for their pain
* Patients who have had pain \<3 months
* Presence of serious medical illness
* Pregnant females
* Use of P450 modifying medications.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hemp synergistics

UNKNOWN

Sponsor Role collaborator

Advanced Pain and Rehab Specialists

OTHER

Sponsor Role lead

Responsible Party

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Anuradha Anand

Medical Director/Physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Advanced Pain and Rehab Specialists

Hermitage, Pennsylvania, United States

Site Status

Countries

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United States

Central Contacts

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Anuradha Anand, MD

Role: CONTACT

7243087401

Facility Contacts

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Anuradha Anand, MD

Role: primary

724-308-7401

Other Identifiers

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AA00001

Identifier Type: -

Identifier Source: org_study_id

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