Immunopathology of Polymyalgia Rheumatica on Shoulder Bursae's Biopsies
NCT ID: NCT04727879
Last Updated: 2023-08-01
Study Results
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Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2021-04-07
2022-08-13
Brief Summary
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However, in systemic autoimmune or inflammatory pathologies, serum immunological mechanisms are rarely a reflection of intra-tissue mechanisms.
In the specific case of PMR, there are few data concerning muscular or joint immunological modifications. The investigators now wish to study the immunological modifications occurring at the tissue sites of interest, in particular in the shoulder bursae
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Control
Witnesses recruited into the orthopedic surgery department will be offered a synovial membrane biopsy during a shoulder surgery in the context of mechanical pathology.
Synovial membrane biopsy with puncture of synovial fluid
The biopsy of the shoulder bursae will be carried out thanks to a device Tru-cut (Tru-Cut Biopsy Needle), minimally invasive, introduced, as during an infiltration, within the bursa serosa.
Blood sample
A blood sample taken during routine care and unused will also be collected from patients and controls for immunoassays.
PMR
Patients with PMR will be offered biopsy of the synovial membrane with puncture of synovial fluid during cortisone infiltration for analgesic purposes. In case of associated peripheric arthritis, the patient will also be offered a joint fluid sample during a cortisonic infiltration for analgesic purposes, performed as part of routine care
The study-specific examination that is not part of current practice is the synovial biopsy performed during the cortisonic infiltration procedure.
Synovial membrane biopsy with puncture of synovial fluid
The biopsy of the shoulder bursae will be carried out thanks to a device Tru-cut (Tru-Cut Biopsy Needle), minimally invasive, introduced, as during an infiltration, within the bursa serosa.
Joint fluid sampling
In case of associated peripheric arthritis, the patient will also be offered a sample of joint fluid during a cortisonic infiltration for analgesic purposes, performed as part of routine care.
Blood sample
A blood sample taken during routine care and unused will also be collected from patients and controls for immunoassays.
Interventions
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Synovial membrane biopsy with puncture of synovial fluid
The biopsy of the shoulder bursae will be carried out thanks to a device Tru-cut (Tru-Cut Biopsy Needle), minimally invasive, introduced, as during an infiltration, within the bursa serosa.
Joint fluid sampling
In case of associated peripheric arthritis, the patient will also be offered a sample of joint fluid during a cortisonic infiltration for analgesic purposes, performed as part of routine care.
Blood sample
A blood sample taken during routine care and unused will also be collected from patients and controls for immunoassays.
Eligibility Criteria
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Inclusion Criteria
* Addressed for PMR (diagnosis OR relapse)
* Score greater than or equal to 4 (without ultrasound criteria) or greater than or equal to 6 (with ultrasound criteria), according to the ACR / EULAR 2012 criteria for polymyalgia rheumatica, and suffering from bilateral scapular pain as well as an increased CRP level .
* Thickening of more than 2mm at least one shoulder bursae in ultrasound
* DAS-PPR\> = 10
For witnesses:
\- Shoulder surgery scheduled for mechanical pathology
Exclusion Criteria
* MRI with Gadolinium injection in the previous month- Clinical or paraclinical signs of giant cell arteritis
* Patient under protective measure or unable to consent
* Active cancer
* Active infection
For the cases:
\- History of biotherapy treatment
For witnesses:
* History of inflammatory rheumatism
* Active inflammatory rheumatism
50 Years
ALL
No
Sponsors
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University Hospital, Brest
OTHER
Responsible Party
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Locations
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CHU de Brest - Service de rhumatologie
Brest, , France
Countries
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Other Identifiers
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29BRC20.0158
Identifier Type: -
Identifier Source: org_study_id
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