Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
25 participants
OBSERVATIONAL
2021-03-04
2023-02-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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Non-patient volunteers
5 non-patient volunteers for testing of protocol to allow for the ascertaining of good quality data prior to the scanning of patients.
Oxygen Enhanced MRI scan
Dynamic MRI scanning switching from breathing room air to high concentration oxygen part way through the scan.
Patients
50 patients to be scanned with the oxygen enhanced MRI scan protocol prior to definitive curative intent therapy.
Oxygen Enhanced MRI scan
Dynamic MRI scanning switching from breathing room air to high concentration oxygen part way through the scan.
Interventions
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Oxygen Enhanced MRI scan
Dynamic MRI scanning switching from breathing room air to high concentration oxygen part way through the scan.
Eligibility Criteria
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Inclusion Criteria
* Signed written informed consent
* Histologically proven or strong clinical suspicion of squamous cell carcinoma of the head and neck
* Suitable for undergoing radical radiotherapy or chemoradiotherapy according to local protocols within the head and neck Cancer MDT
* Age 18 years and above
* Adequate physical fitness (WHO performance status 0 to 2)
* Signed written informed consent
Exclusion Criteria
* Severe Chronic Obstructive Pulmonary Disease (COPD) who are at risk of type 2 respiratory failure or require supplemental oxygen
* Volunteers who are pregnant as identified through the NUH standard MR safety screening protocol
* Poor physical fitness (WHO performance status greater than 2)
* Contraindications to MRI scans as identified following completion of the NUH standard MR safety screening protocol
* Severe Chronic Obstructive Pulmonary Disease (COPD) who are at risk of type 2 respiratory failure or require supplemental oxygen
* Patients who are pregnant or breast-feeding (due to IV contrast use in the routine clinical scan) as identified through the NUH standard MR safety screening protocol
18 Years
99 Years
ALL
Yes
Sponsors
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Nottingham University Hospitals NHS Trust
OTHER
Responsible Party
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Principal Investigators
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Rafal Panek, PhD
Role: PRINCIPAL_INVESTIGATOR
Nottingham University Hospitals NHS Trust
Locations
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Queens Medical Centre
Nottingham, Nottinghamshire, United Kingdom
Countries
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References
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McCabe A, Martin S, Rowe S, Shah J, Morgan PS, Borys D, Panek R. Oxygen-enhanced MRI assessment of tumour hypoxia in head and neck cancer is feasible and well tolerated in the clinical setting. Eur Radiol Exp. 2024 Mar 6;8(1):27. doi: 10.1186/s41747-024-00429-1.
Other Identifiers
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20MP001
Identifier Type: -
Identifier Source: org_study_id
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