Performance of 18F-FDG Micro-PET-CT in the Assessment of Surgical Margins in Head and Neck Cancer

NCT ID: NCT07285564

Last Updated: 2025-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-11-07

Study Completion Date

2026-06-15

Brief Summary

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The purpose of this study is to evaluate the diagnostic performance of 18F-FDG micro-PET-CT in malignant Head and neck cancer compared to definitive histological analysis (gold standard).

Detailed Description

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In approximately 20% of cases, surgical margins are considered insufficient. The only tool currently available intraoperatively to assess the quality of surgical resection is the extemporaneous examination. This has a sensitivity of only 10%.

The objective is therefore to evaluate the performance of another tool, available intraoperatively, to help surgeons assess the quality of their resection. Currently, micro-PET-CT allows for the evaluation of surgical specimens (CE marking and FDA approval obtained). Its performance in the evaluation of surgical margins remains to be demonstrated. This is the subject of the present study.

Conditions

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Head & Neck Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Experimental

PET/CT of the specimen after surgery

Group Type EXPERIMENTAL

micro PET/CT

Intervention Type DEVICE

PET/T of the speciment after surgery

Interventions

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micro PET/CT

PET/T of the speciment after surgery

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Signed informed consent
* Adult, male or female, aged 18 or over
* Patient with a malignant tumor of the oral cavity, oropharynx, hypopharynx, larynx, sinuses, or salivary glands, regardless of lymph node status (any N) M0, operable
* Member or beneficiary of a social security plan

Exclusion Criteria

* Child-Pugh C liver failure
* Patients under guardianship, conservatorship, or legal protection
* Patients deprived of their liberty
* Pregnant or breastfeeding women
* Hypersensitivity to 18F-FDG or any of its excipients (ethanol or water for injection)
* Uncontrolled diabetes
* Moderate to end-stage renal failure, stage IIIB to V (glomerular filtration rate less than 44 mL/min/1.73 m²)
* Patients unable to understand the study for any reason or to comply with the trial requirements (language, psychological, or geographical issues).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Henri Becquerel

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sebastien Hapdey, PhD

Role: PRINCIPAL_INVESTIGATOR

Centre Henri Becquerel

Lise-Marie Roussel, MD

Role: PRINCIPAL_INVESTIGATOR

Centre Henri Becquerel

Locations

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Centre Henri Becquerel

Rouen, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Lise-Marie Roussel, MD

Role: CONTACT

+33232082222

Doriane Richard, PhD

Role: CONTACT

+33232082985

Facility Contacts

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Lise-Marie Roussel, MD

Role: primary

+33232082222

Other Identifiers

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CHB25.06

Identifier Type: -

Identifier Source: org_study_id