Effect of TIVA With Magnesium Sulfate on IONM in Patients Undergoing Spine Surgery
NCT ID: NCT04716439
Last Updated: 2021-01-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2021-02-28
2021-10-31
Brief Summary
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Detailed Description
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1. Decrease anesthetic consumption
2. Decrease use of muscle relaxants
3. Decrease analgesic consumption
4. Excellent recovery
Patients \& Methods:
* 2 groups (total 50) Randomized Controlled Double Blind (RCDB) Study
* Propofol + remifentanil + saline (Control = C group)
* Propofol + remifentanil + Mgso4 (Magnesium = M group)
* Adult Spine decompression and fixation After getting the Institutional Review Board (IRB) approval, This randomized controlled double blind study includes 2 groups of patients (each group 25) will be enrolled in the study. All patients undergo spine decompression and fixation surgery
Induction:
All patients in the study will receive iv fentanyl 2 mic/kg + propofol 2mg/kg and endotracheal intubation will be facilitated with rocuronium 0.60 mg/ kg. Then anesthesia will be maintained using total intravenous anesthesia with propofol (6-9 mg/kg/hr) + remifentanil (0.03-0.05 mic / kg/ min) Group 1 (C group) : Receive 10 mg/kg /hr 0.9% Normal Saline Group 2 (M group) : Receive 10 mg/kg/hr Magnesium Sulfate
Monitoring:
1. IONM
2. train-of-four (TOF)
3. bispectral index (BIS)
Measurements:
1. IO Anesthetic Consumption
2. IO Hemodynamics
3. somatosensory evoked potential (SSEP), motor evoked potential (MEP), TOF, BIS Readings
4. PO visual analogue scale (VAS) (24hours)
5. PO Morphine Consumption (24hours)
Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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magnesium sulfate effect on IONM reading in spine surgery
one group receives magnesium other do not
Spine Surgery
spine decompression and fixation
Interventions
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Spine Surgery
spine decompression and fixation
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. Liver Cell failure
3. Heart Block
30 Years
60 Years
ALL
No
Sponsors
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King Khalid University Hospital
OTHER
Responsible Party
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Essam M. Manaa (MD)
Assistant Professor & Consultant
Principal Investigators
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ESSAM M MANAA, MD
Role: PRINCIPAL_INVESTIGATOR
Assistant Professor and Consultant, Anesthesia Department, Faculty of Medicine, KKUH, KSU, Riyadh, Saudi Arabia
Locations
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Anesthesia Department, Faculty of Medicine, King Khalid University Hospital, King Saud University
Riyadh, , Saudi Arabia
Countries
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Central Contacts
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Other Identifiers
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E-20-4965
Identifier Type: -
Identifier Source: org_study_id
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