Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?

NCT ID: NCT04711746

Last Updated: 2025-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

544 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-01

Study Completion Date

2026-01-31

Brief Summary

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The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders. Venous thrombosis are frequent in these disorders. The purpose of this project is to determine if CHIP is frequent in unprovoked pulmonary embolism and could be part of the pathophysiology.

Detailed Description

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Conditions

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Pulmonary Embolism Hematopoiesis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Previous proximal unprovoked pulmonary embolism

Group Type EXPERIMENTAL

blood sample

Intervention Type BIOLOGICAL

Blood sample withdrawal in order to perform DNA sequencing

Previous proximal provoked pulmonary embolism

Group Type ACTIVE_COMPARATOR

blood sample

Intervention Type BIOLOGICAL

Blood sample withdrawal in order to perform DNA sequencing

Interventions

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blood sample

Blood sample withdrawal in order to perform DNA sequencing

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening.
* For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening.

Exclusion Criteria

* Age superior to 65 years old,
* Active cancer
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Amiens

Amiens, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Simon SOUDET, MD

Role: CONTACT

03 22 88 72 89

Facility Contacts

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SOUDET Simon, MD

Role: primary

03 22 88 72 89

Other Identifiers

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PI2020_843_0117

Identifier Type: -

Identifier Source: org_study_id

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