Ultrasound to Detect Splenomegally in Patients With Isolated Thrombocytopenia

NCT ID: NCT07182760

Last Updated: 2025-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-10-31

Study Completion Date

2027-05-31

Brief Summary

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Investigate prevalence of splenomegally in patients with isolated thrombocytopenia.

Asess effect of splenomegally in clinical picture ,Complication, treatment response and disease outcome To explain possible causes of splenomegally in patients with isolated thrombocytopenia

Detailed Description

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Conditions

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Primary Immune Thrombocytopenic Purpura Amegakaryocytic Aplasia Unilineage Myelodysplastic Syndrome ( Megakaryocyte Dysplasia) Lymphoproliferative Disorder With Secondary ITP Autoimmune Diseases With Secondary ITP

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Group 1a patients with isolated thrombocytopenia and splenomegaly

Group 1b patients with isolated thrombocytopenia without splenomegaly.

No interventions assigned to this group

Group 1b patients with isolated thrombocytopenia without splenomegaly.

Group 1b patients with isolated thrombocytopenia without splenomegaly.

No interventions assigned to this group

Group 2 healthy volunteers.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients more than 18 years admitted with isolated thrombocytopenia due to primary Immune thrombocytopenic purpura amegakaryocytic aplasia Unilineage myelodysplastic syndrome ( megakaryocyte dysplasia) lymphoproliferative disorder with secondary ITP autoimmune diseases with secondary ITP Willingness to participate in the study Admitted patients or those who follow at hematology outpatients clinic

Exclusion Criteria

EDTA induced pseudothrombocytopenia Platelet satellitism Drug induced thrombocytopenia Heparin induced thrombocytopenia / thrombosis syndrome post transfusion purpura Disseminated intravascular coagulopathy patients less than 18 years old patients with bicytopenia or pancytopenia Pregnancy

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Karim Ashraf hussein youssef

Resident in Internal Medicine Department in Assiut University Hospitals

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Karim Ashraf, Resident

Role: CONTACT

+20 ext. 01019954118

References

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Achterbergh R, Vermeer HJ, Curtis BR, Porcelijn L, Aster RH, Deenik W, Daemen-Gubbels C. Thrombocytopenia in a nutshell. Lancet. 2012 Feb 25;379(9817):776. doi: 10.1016/S0140-6736(11)61643-7. No abstract available.

Reference Type BACKGROUND
PMID: 22364760 (View on PubMed)

Arnold J, Ouwehand WH, Smith GA, Cohen H. A young woman with petechiae. Lancet. 1998 Aug 22;352(9128):618. doi: 10.1016/s0140-6736(98)05194-0. No abstract available.

Reference Type BACKGROUND
PMID: 9746024 (View on PubMed)

LAVY R. THROMBOCYTOPENIC PURPURA DUE TO LUPINUS TERMIS BEAN. J Allergy. 1964 Sep-Oct;35:386-9. doi: 10.1016/0021-8707(64)90065-6. No abstract available.

Reference Type BACKGROUND
PMID: 14216353 (View on PubMed)

Kam T, Alexander M. Drug-induced immune thrombocytopenia. J Pharm Pract. 2014 Oct;27(5):430-9. doi: 10.1177/0897190014546099. Epub 2014 Aug 17.

Reference Type BACKGROUND
PMID: 25134884 (View on PubMed)

Other Identifiers

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S.I.TH

Identifier Type: -

Identifier Source: org_study_id

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