Study of the Efficacy and Safety of IBI319 in Patients With Advanced Malignant Tumors

NCT ID: NCT04708210

Last Updated: 2022-10-12

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE1
• Total Enrollment: 256 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-04-28
• Study Completion Date: 2023-06-21

Brief Summary

An open-label, multicenter, phase Ia/Ib study to evaluate the safety, tolerance and preliminary efficacy of IBI319 in patients with advanced malignant tumors

Conditions

Advanced Malignant Tumors

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Phase Ia Dose-Escalation Stage: IBI319

Group Type: EXPERIMENTAL

IBI319

Intervention Type: DRUG

Iv infusion day 1 of every 14 or 21 days in Phase Ia until disease progression or loss of clinical benefit.

Interventions

IBI319

Iv infusion day 1 of every 14 or 21 days in Phase Ia until disease progression or loss of clinical benefit.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Subjects able to give voluntary informed consent, understand the study and are willing to follow and complete all the test procedures.

2. Patients with advanced solid tumors or hematological malignancies who had failed standard treatment.

3. Male or female subjects ≥18 years and ≤75 years.

4. At least one measurable lesion (per RECIST version 1.1) in solid tumor patients and at least one measurable and hyper metabolic in 18F-FDG lesion (per Lugano2014) in lymphoma patients

5. Eastern Cooperative Oncology Group (ECOG) Performance Status ≤1.

6. Subjects with life expectancy of ≥ 12 weeks.

7. Subjects must have adequate organ function (liver, kidney function and hematopoietic function tests) prior IBI319 administration

1. Absolute neutrophil count (ANC) ≥1.5 x10^9/L

2. Platelet count ≥ 100 x 10^9/L

3. Hemoglobin ≥ 9 g / dL (whole blood or component transfusion within 7 days before 1st dose of study drug is prohibited)

4. Renal function tests: an estimated glomerular filtration rate (eGFR) ≥ 50 mL/min

5. Liver function tests alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5 x ULN, for patients with known liver cancer or liver metastases, AST and ALT ≤ 5 x ULN

6. Total bilirubin (TBil) ≤1.5 x ULN; If Gilbert's Syndrome may have Bilirubin> 2 x ULN

7. Coagulation tests: APTT ≤ 1.5 x ULN and INR ≤1.5 x ULN

8. Subjects (males and females) of childbearing potential should be willing to use reliable contraception methods that are deemed effective by the investigator from visit 1 through 180 days following the last dose of study drug.

Exclusion Criteria

1. Legal incapacity or limited legal capacity.

2. Pregnancy, lactation, breastfeeding.

3. Prior treatment with an anti-CD137, anti-Programmed Death Receptor (PD)-1, anti-PD-L1, anti-PD-L2, anti-Cytotoxic T-Cell Lymphoma-4 Antigen (CTLA-4) antibody, or any other antibody or drug (except for Ib cohort A and B).

4. NSCLC patients with EGFR mutations or ALK gene rearrangements.

5. Colorectal cancer patients with KRAS mutation / BRAF mutation / HER2 overexpression.

6. Concurrent anticancer treatment or use of other investigational product within 4 weeks before start of trial treatment; major surgery within 4 weeks before start of trial treatment (excluding prior diagnostic biopsy).

7. Failure to recover from adverse events from the most recent anti-tumor treatment to CTCAE ≤ grade 1 or baseline with the exception of alopecia.

8. Acute or chronic hepatitis B, hepatitis C or human immunodeficiency virus (HIV) infection.

9. Subjects with CNS metastasis unless they are asymptomatic or adequately treated with radiotherapy and/or surgery and subjects are neurologically stable with minimal residual symptoms/signs.

-

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Innovent Biologics (Suzhou) Co. Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Yilong Wu

Role: PRINCIPAL_INVESTIGATOR

Guangdong Provincial People's Hospital

Locations

Guangdong Provincial People's Hospital

Guangdong, , China

Countries

China

Other Identifiers

CIBI319A101

Identifier Type: -

Identifier Source: org_study_id