Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
200000 participants
OBSERVATIONAL
2020-03-01
2023-12-31
Brief Summary
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The Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) created a population-based registry of suspected and confirmed consecutive cases of COVID-19. The purpose of this registry is to derive and validate clinical decision rules, evaluate diagnostic tests and vaccine effectiveness, and complete cohort, case-control and observational studies to inform the pandemic response.
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Detailed Description
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Data will be abstracted from the medical chart and entered into a central, web-based REDCap database. The investigators adopted the ISARIC variables into the database where there was a match. The investigators will develop standardized operating procedures for screening of potentially eligible patients, data entry and follow-up. Current data dictionaries are kept on the registry's website (https://canadiancovid19registry.org/).
At 30 days, the investigators will contact patients by telephone to obtain verbal consent for follow-up. The investigators will measure the Veterans Rand 12-item Health Survey (VR12), calculate the WHO Ordinal Outcome Scale and ask contextual questions in consenting patients. The VR12 will be measured at 60 days, and 6 and 12 months. The contextual questions were developed with input from patients with lived experience with COVID-19 infection and addressed cultural, racial, gender, socioeconomic and self-isolation issues.
The Health Data Research Network facilitated the development of a unique data flow of personal health identifiers and study identification numbers from each province for all participating institutes. This will allow linkage of registry data with national administrative data repositories.
Conditions
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Study Design
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COHORT
OTHER
Study Groups
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Registry participants
Patients presenting to participating emergency departments with suspected and or confirmed COVID-19.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Meeting the WHO suspect COVID-19 criteria: Fever (self-reported or subjective fever) and at least one symptom/sign of respiratory illness (e.g., flu-like illness, cough, shortness of breath)
* Presenting to the emergency department and tested for COVID-19 in the emergency department
* Presenting to the emergency department within 14 days of a positive COVID-19 (by self-report or in medical chart) and presents with clinical symptoms consistent with COVID-19
* Tested for COVID-19 in the emergency department, or within 24 hours after emergency department arrival.
Exclusion Criteria
* Patients tested for COVID-19 in the context of an elective admission (e.g., planned hip revision)
* Patients tested for COVID-19 and seen in the emergency department directly by another service (e.g., trauma team activation)
ALL
No
Sponsors
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Genome British Columbia
INDUSTRY
Canadian Institutes of Health Research (CIHR)
OTHER_GOV
Canadian Critical Care Trials Group
OTHER
University of British Columbia
OTHER
Responsible Party
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Corinne Hohl
Associate Professor
Principal Investigators
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Corinne M Hohl, MD, MSc
Role: PRINCIPAL_INVESTIGATOR
University of British Columbia
Locations
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Foothills Medical Centre
Calgary, Alberta, Canada
Peter Lougheed Centre
Calgary, Alberta, Canada
Rockyview General Hospital
Calgary, Alberta, Canada
South Health Campus
Calgary, Alberta, Canada
Northeast Community Health Centre
Edmonton, Alberta, Canada
Royal Alexandra Hospital
Edmonton, Alberta, Canada
University of Alberta Hospital
Edmonton, Alberta, Canada
Abbotsford Regional Hospital
Abbotsford, British Columbia, Canada
Royal Inland Hospital
Kamloops, British Columbia, Canada
Kelowna General Hospital
Kelowna, British Columbia, Canada
Royal Columbian Hospital
New Westminster, British Columbia, Canada
Lions Gate Hospital
North Vancouver, British Columbia, Canada
Eagle Ridge Hospital
Port Moody, British Columbia, Canada
Surrey Memorial Hospital
Surrey, British Columbia, Canada
Mount Saint Joseph Hospital
Vancouver, British Columbia, Canada
St. Paul's Hospital
Vancouver, British Columbia, Canada
Vancouver General Hospital
Vancouver, British Columbia, Canada
Saint John Regional Hospital
Saint John, New Brunswick, Canada
Dartmouth General Hospital
Dartmouth, Nova Scotia, Canada
Halifax Infirmary
Halifax, Nova Scotia, Canada
Cobequid Community Health Centre
Lower Sackville, Nova Scotia, Canada
Hants Community Hospital
Windsor, Nova Scotia, Canada
Health Science North
Greater Sudbury, Ontario, Canada
Hamilton General Hospital
Hamilton, Ontario, Canada
Juravinski Hospital
Hamilton, Ontario, Canada
Hotel Dieu Hospital
Kingston, Ontario, Canada
Kingston General Hospital
Kingston, Ontario, Canada
London Health Sciences Centre (University Hospital)
London, Ontario, Canada
London Health Sciences Centre (Victoria Hospital)
London, Ontario, Canada
The Ottawa Hospital - Civic Campus
Ottawa, Ontario, Canada
The Ottawa Hospital - General Campus
Ottawa, Ontario, Canada
North York General Hospital
Toronto, Ontario, Canada
Sunnybrook Hospital
Toronto, Ontario, Canada
Toronto Western Hospital
Toronto, Ontario, Canada
Hôtel-Dieu de Lévis
Lévis, Quebec, Canada
Hôpital du Sacré-Coeur
Montreal, Quebec, Canada
Jewish General Hospital
Montreal, Quebec, Canada
Montréal General Hospital (MUHC)
Montreal, Quebec, Canada
Royal Victoria Hospital (MUHC)
Montreal, Quebec, Canada
Centre Hospitalier de l'Université Laval (CHU de Québec)
Québec, Quebec, Canada
Hôpital de l'Enfant-Jésus (CHU de Québec)
Québec, Quebec, Canada
Hôpital du Saint-Sacrement (CHU de Québec)
Québec, Quebec, Canada
Hôpital Saint-François d'Assise (CHU de Québec)
Québec, Quebec, Canada
Hôtel-Dieu de Québec (CHU de Québec)
Québec, Quebec, Canada
Institut universitaire de cardiologie et de pneumologie de Québec
Québec, Quebec, Canada
Pasqua Hospital
Regina, Saskatchewan, Canada
Regina General Hospital
Regina, Saskatchewan, Canada
Royal University
Saskatoon, Saskatchewan, Canada
Saskatoon City Hospital
Saskatoon, Saskatchewan, Canada
St Paul's Hospital
Saskatoon, Saskatchewan, Canada
Countries
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Central Contacts
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References
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Rosychuk RJ, Khangura JK, Ortiz SS, Cheng I, Bielska IA, Yan J, Morrison LJ, Hayward J, Grant L, Hohl CM; Canadian COVID-19 Rapid Response Network (CCEDRRN) for the Network of Canadian Emergency Researchers (NCER). Characteristics and outcomes of patients with COVID-19 who return to the emergency department: a multicentre observational study by the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN). Emerg Med J. 2024 Mar 21;41(4):210-217. doi: 10.1136/emermed-2023-213277.
Hohl CM, Cragg A, Purssell E, McAlister FA, Ting DK, Scheuermeyer F, Stachura M, Grant L, Taylor J, Kanu J, Hau JP, Cheng I, Atzema CL, Bola R, Morrison LJ, Landes M, Perry JJ, Rosychuk RJ; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group. Comparing methods to classify admitted patients with SARS-CoV-2 as admitted for COVID-19 versus with incidental SARS-CoV-2: A cohort study. PLoS One. 2023 Sep 26;18(9):e0291580. doi: 10.1371/journal.pone.0291580. eCollection 2023.
Archambault PM, Rosychuk RJ, Audet M, Bola R, Vatanpour S, Brooks SC, Daoust R, Clark G, Grant L, Vaillancourt S, Welsford M, Morrison LJ, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators; Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group. Accuracy of Self-Reported COVID-19 Vaccination Status Compared With a Public Health Vaccination Registry in Quebec: Observational Diagnostic Study. JMIR Public Health Surveill. 2023 Jun 16;9:e44465. doi: 10.2196/44465.
Lin K, Xu K, Daoust R, Taylor J, Rosychuk RJ, Hau JP, Davis P, Clark G, McRae AD, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers, the Canadian Critical Care Trials Group. Prognostic association between d-dimer thresholds and 30-day pulmonary embolism diagnosis among emergency department patients with suspected SARS-CoV-2 infection: a Canadian COVID-19 Emergency Department Rapid Response Network study. CJEM. 2023 Feb;25(2):134-142. doi: 10.1007/s43678-022-00440-8. Epub 2023 Jan 10.
Davis P, Rosychuk R, Hau JP, Cheng I, McRae AD, Daoust R, Lang E, Turner J, Khangura J, Fok PT, Stachura M, Brar B, Hohl CM; CCEDRRN investigators, and for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study. BMJ Open. 2022 Aug 10;12(8):e057852. doi: 10.1136/bmjopen-2021-057852.
Hohl CM, Rosychuk RJ, Hau JP, Hayward J, Landes M, Yan JW, Ting DK, Welsford M, Archambault PM, Mercier E, Chandra K, Davis P, Vaillancourt S, Leeies M, Small S, Morrison LJ; Canadian COVID-19 Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers, for the Canadian Critical Care Trials Group. Treatments, resource utilization, and outcomes of COVID-19 patients presenting to emergency departments across pandemic waves: an observational study by the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN). CJEM. 2022 Jun;24(4):397-407. doi: 10.1007/s43678-022-00275-3. Epub 2022 Apr 1.
Hohl CM, Rosychuk RJ, Archambault PM, O'Sullivan F, Leeies M, Mercier E, Clark G, Innes GD, Brooks SC, Hayward J, Ho V, Jelic T, Welsford M, Sivilotti MLA, Morrison LJ, Perry JJ; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. The CCEDRRN COVID-19 Mortality Score to predict death among nonpalliative patients with COVID-19 presenting to emergency departments: a derivation and validation study. CMAJ Open. 2022 Feb 8;10(1):E90-E99. doi: 10.9778/cmajo.20210243. Print 2022 Jan-Mar.
McRae AD, Hohl CM, Rosychuk R, Vatanpour S, Ghaderi G, Archambault PM, Brooks SC, Cheng I, Davis P, Hayward J, Lang E, Ohle R, Rowe B, Welsford M, Yadav K, Morrison LJ, Perry J; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. CCEDRRN COVID-19 Infection Score (CCIS): development and validation in a Canadian cohort of a clinical risk score to predict SARS-CoV-2 infection in patients presenting to the emergency department with suspected COVID-19. BMJ Open. 2021 Dec 2;11(12):e055832. doi: 10.1136/bmjopen-2021-055832.
Hohl CM, Rosychuk RJ, McRae AD, Brooks SC, Archambault P, Fok PT, Davis P, Jelic T, Turner JP, Rowe BH, Mercier E, Cheng I, Taylor J, Daoust R, Ohle R, Andolfatto G, Atzema C, Hayward J, Khangura JK, Landes M, Lang E, Martin I, Mohindra R, Ting DK, Vaillancourt S, Welsford M, Brar B, Dahn T, Wiemer H, Yadav K, Yan JW, Stachura M, McGavin C, Perry JJ, Morrison LJ; Canadian COVID-19 Emergency Department Rapid Response Network investigators and for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Development of the Canadian COVID-19 Emergency Department Rapid Response Network population-based registry: a methodology study. CMAJ Open. 2021 Mar 17;9(1):E261-E270. doi: 10.9778/cmajo.20200290. Print 2021 Jan-Mar.
Other Identifiers
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H20-01015
Identifier Type: -
Identifier Source: org_study_id
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