Population Pharmacokinetics of Vancomycin, Meropenem, Milrinone, Dexmedetomidine and Fentanyl in Pediatric Patients During Extracorporeal Membrane Oxygenation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-07

Study Completion Date

2023-04-30

Brief Summary

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Extracorporeal membrane oxygenation (ECMO) has been used primarily in newborns since it was first successfully implemented in the 1970s, and has recently increased use in infants and young children. Venoarterial ECMO (VA-ECMO) is a temporary mechanical circulatory support for patients with cardiac failure. Because ECMO is invasive, appropriate use of antimicrobial agent, analgesic and sedatives is important to promote recovery. However, a large variability in drugs pharmacokinetics is expected in pediatric ECMO patients due to the combination of ECMO, drug characteristics and disease factor. This study aimed to evaluate whether the PK of drugs is influenced by VA-ECMO and to recommend the optimal dosing strategies for proposed drugs in pediatric patients receiving VA-ECMO.

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Detailed Description

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Conditions

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Pediatric Patients Receiving Venoarterial Extracorporeal Membrane Oxygenation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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On ECMO

patients who is receiving vancomycin or meropenem or milrinone or dexmedetomidine or fentanyl during ECMO support.

No interventions assigned to this group

Off ECMO

patients who is receiving vancomycin or meropenem or milrinone or dexmedetomidine or fentanyl after weaning off ECMO.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* \<19 years old
* receiving VA ECMO in Severance Hospital, Yonsei University Health System.
* receiving one of these drugs: vancomycin or meropenem or milrinone or dexmedetomidine or fentanyl
* agreed to participate