Craniofacial Imaging With 3D MRI: an Alternative to Ionising Radiation
NCT ID: NCT04695938
Last Updated: 2021-01-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
80 participants
INTERVENTIONAL
2020-11-27
2023-07-31
Brief Summary
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Whilst in many cases the abnormal head shape provides doctors with the underlying diagnosis, it is necessary to confirm this using imaging. A CT scan involves using multiple x-rays to build a picture of the part of the body being examined. X-rays are associated with potential long term harm, particularly in young children who have longer to incur those risks. MRI uses magnets and radiowaves to create images of the body, and therefore a radiation-free method of imaging.
The investigators have previously shown in a pilot group that a specific MRI technique ("Black Bone") can distinguish between normal and prematurely fused cranial sutures, and that the images can be reconstructed in 3D in the same way as CT.
The investigators now need to confirm the findings in a larger patient group, and develop automated methods of creating 3D images of the bone.
Children in whom there is clinical suspicion of craniosynostosis will be recruited for MRI examination. In children who are already undergoing MRI examination of the head (for any indication), the investigators will add on bone specific sequences.
There are no known long term risks associated with MRI, and no contrast medium is required. Anonymised MRI data will be used to further develop our 3D techniques.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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MRI
MRI examination
MRI
MRI examination with Black Bone, and ultrashort/zero echo time MRI techniques
Interventions
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MRI
MRI examination with Black Bone, and ultrashort/zero echo time MRI techniques
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Children who require sedation/anaesthesia solely for the purpose of research MRI
0 Months
2 Years
ALL
No
Sponsors
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Great Ormond Street Hospital for Children NHS Foundation Trust
OTHER
Oxford University Hospitals NHS Trust
OTHER
Cambridge University Hospitals NHS Foundation Trust
OTHER
University of Cambridge
OTHER
Responsible Party
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Dr Karen A Eley
Clinical Lecturer in Radiology
Locations
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University of Cambridge
Cambridge, , United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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18/WA/0155
Identifier Type: -
Identifier Source: org_study_id
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