Pharmacogenetics Associated With IV Ketamine

NCT ID: NCT04695405

Last Updated: 2021-08-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

85 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-21

Study Completion Date

2021-07-02

Brief Summary

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The Canadian Rapid Treatment Center of Excellence (CRTCE) is a healthcare facility principally focused on providing best practices of intravenous ketamine treatment to adult patients suffering from treatment resistant depression. Patients who have received IV ketamine at the clinic are eligible to participate in this study where genetic biomarkers are correlated with response to IV ketamine.

Detailed Description

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Conditions

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Treatment Resistant Depression

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

PROSPECTIVE

Study Groups

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Treatment-Resistant Depression

Patients, who previously received intravenous ketamine, will be asked to provide genetic samples in order to assess relationships between response and genetic markers.

Saliva Genetic Samples

Intervention Type GENETIC

Patients will provide two saliva swabs containing genetic materials.

Interventions

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Saliva Genetic Samples

Patients will provide two saliva swabs containing genetic materials.

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

1. Must have received IV ketamine previously to treat Treatment-Resistant Depression
2. Between the ages of 18-65 years old.
3. Clinical diagnosis of MDD
4. Individuals may have had comorbid psychiatric conditions (e.g., anxiety), but the comorbid psychiatric condition cannot be the primary clinical concern.
5. Ability to provide informed consent

Exclusion Criteria

1. Individuals who meet DSM 5 criteria for a substance use and/or alcohol use disorder in the past 3 months.
2. Individuals who are currently experiencing psychotic symptoms as part of an MDE (mood congruent/mood incongruent).
3. Individuals who are unable to consent to the procedure.
4. Individuals who are unable to adhere to the protocol in its totality
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Brain and Cognition Discovery Foundation

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Joshua D Rosenblat, MD, MSc

Role: PRINCIPAL_INVESTIGATOR

Canadian Rapid Treatment Center of Excellence

Locations

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Canadian Rapid Treatment Centre of Excellence

Mississauga, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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Ket-PGx

Identifier Type: -

Identifier Source: org_study_id

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