Kinesiophobia, Quality of Life, and Cognitive Functions in Fibromyalgia Syndrome

NCT ID: NCT04695288

Last Updated: 2022-08-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-01

Study Completion Date

2022-07-25

Brief Summary

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Although one of the most evidence-based treatment protocols is based on exercise strategies in patients with Fibromyalgia Syndrome, fear and avoidance of physical activity; named 'Kinesiophobia' may hinder the patients from the exercises. Cognitive dysfunctions are seen frequently in Fibromyalgia Syndrome. The aim of this study, to assess the relationship between kinesiophobia and cognitive functions, disease severity, quality of life, physical activity level, pain intensity, and anxiety/depression level in Fibromyalgia patients. Additionally, the investigators aimed to compare the kinesiophobia level and cognitive functions between patients with Fibromyalgia Syndrome and control subjects.

Detailed Description

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Cognitive dysfunction, including learning difficulties, memory, attention, and executive dysfunctions are frequent in fibromyalgia syndrome. Kinesiophobia is defined as fear and avoidance of physical activities, and it can lead to increased disability in patients with chronic pain. Although there is a relationship between cognitive functions and physical performance in Fibromyalgia Syndrome, the relationship between kinesiophobia, fibrofog, and quality of life are required to be investigated.

The aims of this study are:

1. To compare the kinesiophobia and cognitive functions in Fibromyalgia Syndrome with healthy volunteers
2. To examine the relationship between the severity of kinesiophobia, cognitive functions, disease activity, quality of life, physical activity level, depression and anxiety severity in Fibromyalgia Syndrome.

The hypothesis is, the patients diagnosed with Fibromyalgia Syndrome have higher kinesiophobia severity and worse cognitive functions, and also that kinesiophobia severity is associated with cognitive dysfunction, disease severity, physical activity level, and psychiatric symptoms in patients with Fibromyalgia Syndrome.

Conditions

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Fibromyalgia Kinesiophobia Cognitive Dysfunction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Fibromyalgia Syndrome

100 participants with a diagnosis of Fibromyalgia Syndrome according to the 2016 revised American College of Rheumatology diagnostic criteria.

No interventions assigned to this group

Control subjects

60 healthy participants do not meet the exclusion criteria of the study.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

-Fibromyalgia Syndrome

Exclusion Criteria

* Education year \< 5
* Inflammatory rheumatic disease
* Malignancy
* Psychiatric disease
* Alcohol/substance addiction
* Central nervous system disease
* History of head trauma
* Chronic pain conditions other than Fibromyalgia Syndrome
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Bozyaka Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Şeniz Akçay

Study Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Elcin Ergez, MD

Role: PRINCIPAL_INVESTIGATOR

University of Health Sciences Izmir Bozyaka Training and Research Hospital

Seniz Akcay, Assoc Prof

Role: STUDY_DIRECTOR

University of Health Sciences Izmir Bozyaka Training and Research Hospital

Nesibe Dogan, Specialist

Role: STUDY_CHAIR

University of Health Sciences Izmir Bozyaka Training and Research Hospital

Dursun Hakan Delibas, Specialist

Role: STUDY_CHAIR

University of Health Sciences Izmir Bozyaka Training and Research Hospital

Locations

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University of Health Sciences Izmir Bozyaka Training and Research Hospital

Izmir, Karabaglar, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Mease P. Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatment. J Rheumatol Suppl. 2005 Aug;75:6-21.

Reference Type BACKGROUND
PMID: 16078356 (View on PubMed)

Katz RS, Heard AR, Mills M, Leavitt F. The prevalence and clinical impact of reported cognitive difficulties (fibrofog) in patients with rheumatic disease with and without fibromyalgia. J Clin Rheumatol. 2004 Apr;10(2):53-8. doi: 10.1097/01.rhu.0000120895.20623.9f.

Reference Type BACKGROUND
PMID: 17043464 (View on PubMed)

Denison E, Asenlof P, Lindberg P. Self-efficacy, fear avoidance, and pain intensity as predictors of disability in subacute and chronic musculoskeletal pain patients in primary health care. Pain. 2004 Oct;111(3):245-252. doi: 10.1016/j.pain.2004.07.001.

Reference Type BACKGROUND
PMID: 15363867 (View on PubMed)

KoCyIGIt BF, Akaltun MS. Kinesiophobia Levels in Fibromyalgia Syndrome and the Relationship Between Pain, Disease Activity, Depression. Arch Rheumatol. 2020 Feb 7;35(2):214-219. doi: 10.46497/ArchRheumatol.2020.7432. eCollection 2020 Jun.

Reference Type BACKGROUND
PMID: 32851370 (View on PubMed)

Turk DC, Robinson JP, Burwinkle T. Prevalence of fear of pain and activity in patients with fibromyalgia syndrome. J Pain. 2004 Nov;5(9):483-90. doi: 10.1016/j.jpain.2004.08.002.

Reference Type BACKGROUND
PMID: 15556826 (View on PubMed)

Russek L, Gardner S, Maguire K, Stevens C, Brown EZ, Jayawardana V, Mondal S. A cross-sectional survey assessing sources of movement-related fear among people with fibromyalgia syndrome. Clin Rheumatol. 2015 Jun;34(6):1109-19. doi: 10.1007/s10067-014-2494-5. Epub 2014 Jan 31.

Reference Type BACKGROUND
PMID: 24481649 (View on PubMed)

Other Identifiers

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01/12/2020-297

Identifier Type: -

Identifier Source: org_study_id

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