Demineralized Bone Matrix Rotator Cuff Study

NCT ID: NCT04686396

Last Updated: 2021-08-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-01

Study Completion Date

2024-09-30

Brief Summary

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Patients undergoing rotator cuff repair surgery will experience improved tendon healing with the use of demineralized bone matrix augmentation.

Detailed Description

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This is a prospective randomized study comparing the outcomes of patient undergoing rotator cuff repair with either an interpositional procedure administering demineralized bone matrix (DBM), or a control group without demineralized bone matrix. Patient outcomes will be collected and compared between the two cohorts up to a five (5) year post-operative period and will include a range of subjective and functional outcomes, along with radiographic imaging.

Conditions

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Rotator Cuff Injuries

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Patients will be randomized to have either the addition of demineralized bone matrix to their procedure (Interpositional Group), or standard Rotator Cuff repair without demineralized bone matrix administered (Control group).
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants
Randomization shall be performed during surgery after intra-operative inclusion/exclusion eligibility has been met.

Study Groups

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Interpositional Group

Demineralized bone matrix

Group Type EXPERIMENTAL

Demineralized bone matrix

Intervention Type DEVICE

Demineralized bone matrix

Control

Without demineralized bone matrix

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Demineralized bone matrix

Demineralized bone matrix

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* The Subject is between the ages of 40 and 75 years.
* Subject is planning to undergo arthroscopic surgery for full thickness rotator cuff tears (RCT) of supraspinatus and infraspinatus muscles, who are candidates for demineralized bone matrix with BMC.
* Two tendon tear or tear size equal to or greater than 3cm
* Amenable to double-row repair
* Primary rotator cuff tears with or without superior labral tear and/or biceps tear)

Exclusion Criteria

* The Subject is unable or unwilling to sign the Patient Informed Consent, approved by the Institutional Review Board.
* The Subject objects to use of allograft
* Irreparable Rotator Cuff Tear
* Complete full thickness subscapularis tears of \> than the superior 1/3 of the tendon (Lafosse grade 3 and above)
* \< 2 mm joint space of the glenohumeral joint on either an anteroposterior or axillary radiograph
* Recurrent shoulder instability
* Intra-articular injections (steroids) within 1 month of surgery
* RCR revisions
* Subject MRI taken more than 12 months prior to surgery
* Pregnant or planning to become pregnant during the study period
* Workman's compensation case
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Arthrex, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Southern Oregon Orthopedics

Medford, Oregon, United States

Site Status

Countries

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United States

Other Identifiers

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US-1300

Identifier Type: -

Identifier Source: org_study_id

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