Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

NCT ID: NCT04685135

Last Updated: 2025-01-22

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

453 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-23

Study Completion Date

2026-07-02

Brief Summary

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This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.

Detailed Description

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Conditions

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Metastatic Non Small Cell Lung Cancer Advanced Non Small Cell Lung Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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MRTX849

Group Type EXPERIMENTAL

MRTX849

Intervention Type DRUG

21 day cycles

Docetaxel

Group Type ACTIVE_COMPARATOR

Docetaxel

Intervention Type DRUG

21 day cycles

Interventions

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MRTX849

21 day cycles

Intervention Type DRUG

Docetaxel

21 day cycles

Intervention Type DRUG

Other Intervention Names

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adagrasib KRAZATI Taxotere

Eligibility Criteria

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Inclusion Criteria

* Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
* Candidacy to receive treatment with docetaxel.


* Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR
* ECOG performance status 0-2

Exclusion Criteria

* Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, Sotorasib).
* Active brain metastases.


* Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mirati Therapeutics Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution - 012-898

Cerritos, California, United States

Site Status

City of Hope - Duarte (Main Campus)

Duarte, California, United States

Site Status

Local Institution - 012-898 D

Glendale, California, United States

Site Status

Local Institution - 012-910-A

Huntington Beach, California, United States

Site Status

Local Institution - 012-910-C

Irvine, California, United States

Site Status

City Of Hope

Long Beach, California, United States

Site Status

Local Institution - 012-910-F

Long Beach, California, United States

Site Status

Local Institution - 012-910-D

Newport Beach, California, United States

Site Status

Local Institution - 012-898 C

Santa Ana, California, United States

Site Status

Providence Medical Group - Santa Rosa

Santa Rosa, California, United States

Site Status

Local Institution - 012-910-E

Torrance, California, United States

Site Status

Local Institution - 012-951-B

Denver, Colorado, United States

Site Status

SCL Health - Saint Joseph Hospital Cancer Center

Lafayette, Colorado, United States

Site Status

Local Institution - 012-872

Lone Tree, Colorado, United States

Site Status

Local Institution - 012-951-A

Wheat Ridge, Colorado, United States

Site Status

Local Institution - 012-562-B

Fleming Island, Florida, United States

Site Status

Holy Cross Health Fort Lauderdale - Holy Cross Hospital

Fort Lauderdale, Florida, United States

Site Status

21st Century Oncology of Jacksonville - North Lee Street

Jacksonville, Florida, United States

Site Status

Local Institution - 012-562-D

Jacksonville, Florida, United States

Site Status

Local Institution - 012-562-E

Jacksonville, Florida, United States

Site Status

Local Institution - 012-562-A

Jacksonville, Florida, United States

Site Status

Local Institution - 012-562-C

Jacksonville, Florida, United States

Site Status

Local Institution - 012-562-F

Jacksonville, Florida, United States

Site Status

Local Institution - 012-562-G

Jacksonville, Florida, United States

Site Status

Local Institution - 012-562

Jacksonville, Florida, United States

Site Status

Mount Sinai Comprehensive Cancer Center

Miami Beach, Florida, United States

Site Status

Orlando Health University of Florida Health Cancer Center - Head and Neck Center

Orlando, Florida, United States

Site Status

USOR - Woodlands Medical Specialists

Pensacola, Florida, United States

Site Status

Local Institution - 012-839

Plantation, Florida, United States

Site Status

University Cancer & Blood Center (UCBC) - Athens

Athens, Georgia, United States

Site Status

Local Institution - 012-835 - A

Austell, Georgia, United States

Site Status

Local Institution - 012-835 - B

Carrollton, Georgia, United States

Site Status

Local Institution - 012-835 - C

Cartersville, Georgia, United States

Site Status

Local Institution - 012-835 - D

Douglasville, Georgia, United States

Site Status

Northwest Georgia Oncology Centers Wellstar - Marietta

Marietta, Georgia, United States

Site Status

University of Illinois Hospital & Health Sciences System

Chicago, Illinois, United States

Site Status

University of Chicago

Chicago, Illinois, United States

Site Status

Local Institution - 012-972 C

Harvey, Illinois, United States

Site Status

Local Institution - 012-972 A

New Lenox, Illinois, United States

Site Status

Illinois Cancer Specialists - Niles

Niles, Illinois, United States

Site Status

Local Institution - 012-972 B

Orland Park, Illinois, United States

Site Status

Goshen Center for Cancer Care

Goshen, Indiana, United States

Site Status

Local Institution - 012-569

Indianapolis, Indiana, United States

Site Status

Local Institution - 012-569 - B

Lafayette, Indiana, United States

Site Status

Local Institution - 012-569 - C

Lafayette, Indiana, United States

Site Status

Local Institution - 012-569 - A

Mooresville, Indiana, United States

Site Status

Franciscan Health Munster

Munster, Indiana, United States

Site Status

Local Institution - 012-942-B

Chanute, Kansas, United States

Site Status

Local Institution - 012-942-C

Dodge City, Kansas, United States

Site Status

Local Institution - 012-942-D

El Dorado, Kansas, United States

Site Status

Local Institution - 012-942-E

Independence, Kansas, United States

Site Status

Local Institution - 012-942-F

Kingman, Kansas, United States

Site Status

Local Institution - 012-942-G

Liberal, Kansas, United States

Site Status

Local Institution - 012-942-H

McPherson, Kansas, United States

Site Status

Local Institution - 012-942-I

Newton, Kansas, United States

Site Status

Local Institution - 012-942-J

Parsons, Kansas, United States

Site Status

Local Institution - 012-942-K

Pratt, Kansas, United States

Site Status

Local Institution - 012-942-L

Salina, Kansas, United States

Site Status

Local Institution - 012-942-M

Wellington, Kansas, United States

Site Status

Local Institution - 012-820

Westwood, Kansas, United States

Site Status

Local Institution - 012-942-A

Wichita, Kansas, United States

Site Status

Local Institution - 012-942

Wichita, Kansas, United States

Site Status

Local Institution - 012-942-N

Winfield, Kansas, United States

Site Status

Baptist Health Lexington

Lexington, Kentucky, United States

Site Status

Local Institution - 012-911 A

New Orleans, Louisiana, United States

Site Status

Tulane University

New Orleans, Louisiana, United States

Site Status

Local Institution - 012-954 - A

Kennebunk, Maine, United States

Site Status

New England Cancer Specialists - Scarborough

Scarborough, Maine, United States

Site Status

Local Institution - 012-954 - B

Topsham, Maine, United States

Site Status

Frederick Health

Frederick, Maryland, United States

Site Status

Local Institution - 012-974-B

Novi, Michigan, United States

Site Status

Local Institution - 012-974-C

Novi, Michigan, United States

Site Status

Ascension Providence Cancer Center - Southfield

Southfield, Michigan, United States

Site Status

Local Institution - 012-974-A

Southfield, Michigan, United States

Site Status

Central Care Cancer Center - Bolivar

Bolivar, Missouri, United States

Site Status

Local Institution - 012-841 - A

Billings, Montana, United States

Site Status

St. Vincent Healthcare Cancer Centers of Montana

Billings, Montana, United States

Site Status

Sisters of Charity of Leavenworth Health St. Marys

Billings, Montana, United States

Site Status

Astera Cancer Care - East Brunswick

East Brunswick, New Jersey, United States

Site Status

Local Institution - 012-975 - A

Edison, New Jersey, United States

Site Status

Local Institution - 012-975 - B

Monroe, New Jersey, United States

Site Status

Local Institution - 012-975 - C

Somerset, New Jersey, United States

Site Status

Local Institution - 012-975 - D

Somerville, New Jersey, United States

Site Status

Holy Name Medical Center

Teaneck, New Jersey, United States

Site Status

SUNY Upstate Medical University

Syracuse, New York, United States

Site Status

University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States

Site Status

Kettering Health Cancer Center - Main Campus

Kettering, Ohio, United States

Site Status

Oregon Oncology Specialists

Salem, Oregon, United States

Site Status

Lifespan Cancer Institute - Rhode Island Hospital

Providence, Rhode Island, United States

Site Status

Local Institution - 012-960-A

Providence, Rhode Island, United States

Site Status

Prisma Health Cancer Institute - Faris Road

Greenville, South Carolina, United States

Site Status

Avera Cancer Institute

Sioux Falls, South Dakota, United States

Site Status

Texas Oncology - Dallas Fort Worth (DFW) - Arlington Cancer Center North

Arlington, Texas, United States

Site Status

Texas Oncology - Dallas Fort Worth (DFW) - South Austin

Austin, Texas, United States

Site Status

US Oncology Research (USOR)

Irving, Texas, United States

Site Status

Texas Oncology - Sherman

Sherman, Texas, United States

Site Status

Utah Cancer Specialists - UCS Cancer Center

Salt Lake City, Utah, United States

Site Status

Local Institution - 012-976-A

Salt Lake City, Utah, United States

Site Status

Local Institution - 012-976-B

Salt Lake City, Utah, United States

Site Status

Local Institution - 012-976-C

Salt Lake City, Utah, United States

Site Status

Local Institution - 012-976-D

Salt Lake City, Utah, United States

Site Status

Local Institution - 012-976-E

Salt Lake City, Utah, United States

Site Status

Local Institution - 012-976-F

Salt Lake City, Utah, United States

Site Status

Local Institution - 012-976-G

Salt Lake City, Utah, United States

Site Status

Local Institution - 012-976-H

Salt Lake City, Utah, United States

Site Status

Local Institution - 012-976-I

Salt Lake City, Utah, United States

Site Status

Local Institution - 012-814 - B

Arlington, Virginia, United States

Site Status

UVA Health - University Hospital

Charlottesville, Virginia, United States

Site Status

Local Institution - 012-814 - A

Fairfax, Virginia, United States

Site Status

NEXT Virginia

Fairfax, Virginia, United States

Site Status

Local Institution - 012-814 - C

Gainesville, Virginia, United States

Site Status

Local Institution - 012-814 - D

Leesburg, Virginia, United States

Site Status

Local Institution - 012-016

Mackay, Queensland, Australia

Site Status

Local Institution - 012-005

Bedford Park, , Australia

Site Status

Local Institution - 012-004

Clayton, , Australia

Site Status

Townsville University Hospital

Douglas, , Australia

Site Status

Local Institution - 012-013

St Leonards, , Australia

Site Status

Local Institution - 012-019

Tweed Heads, , Australia

Site Status

Cancer Care Wollongong

Wollongong, , Australia

Site Status

Princess Alexandra Hospital

Woolloongabba, , Australia

Site Status

Klinikum Klagenfurt Am Worthersee

Klagenfurt, , Austria

Site Status

Uniklinikum Salzburg

Salzburg, , Austria

Site Status

Wiener Gesundheitsverbund - Klinik Ottakring

Vienna, , Austria

Site Status

Universitair Ziekenhuis Brussel

Brussels, , Belgium

Site Status

Local Institution - 012-157

Edegem, , Belgium

Site Status

Local Institution - 012-155

Ghent, , Belgium

Site Status

Local Institution - 012-151

Gilly, , Belgium

Site Status

Local Institution - 012-158

Hasselt, , Belgium

Site Status

Local Institution - 012-152

Roeselare, , Belgium

Site Status

Algemeen Ziekenhuis Glorieux Ronse

Ronse, , Belgium

Site Status

Local Institution - 012-150

Yvoir, , Belgium

Site Status

Local Institution - 012-164

Hořovice, , Czechia

Site Status

Local Institution - 012-162

Olomouc, , Czechia

Site Status

Vseobecna Fakultni Nemocnice v Praze

Prague, , Czechia

Site Status

Fakultni nemocnice Bulovka

Praha 8 - Liben, , Czechia

Site Status

Local Institution - 012-191-A

Pierre-Bénite, Auvergne-Rhône-Alpes, France

Site Status

Local Institution - 012-191-B

Lyon, Rhone, France

Site Status

Local Institution - 012-194

Brest, , France

Site Status

Hopital Louis Pradel

Bron, , France

Site Status

Local Institution - 012-193

Caen, , France

Site Status

Local Institution - 012-196

Caen, , France

Site Status

Centre Hospitalier Intercommunal de Creteil

Créteil, , France

Site Status

Local Institution - 012-192

Dijon, , France

Site Status

LHopital Nord-Ouest (HNO) - Villefranche-sur-Saone

Gleizé, , France

Site Status

Hopital Michallon

La Tronche, , France

Site Status

Centre Hospitalier Regional Universitaire de Lille

Lille, , France

Site Status

Centre Hospitalier Universitaire Dupuytren 1

Limoges, , France

Site Status

Institut Paoli-Calmettes

Marseille, , France

Site Status

Hopital Nord de Marseille

Marseille, , France

Site Status

Hopital Arnaud de Villeneuve

Montpellier, , France

Site Status

Hopital Emile Muller

Mulhouse, , France

Site Status

Local Institution - 012-685

Nice, , France

Site Status

Centre Hospitalier de Cornouaille - Hopital Laennec

Quimper, , France

Site Status

Institut de Cancerologie de lOuest - Saint-Herblain - Site Rene Gauducheau

Saint-Herblain, , France

Site Status

Hopital Civil

Strasbourg, , France

Site Status

Local Institution - 012-197

Strasbourg, , France

Site Status

Hopital Bretonneau

Tours, , France

Site Status

Gustave Roussy

Villejuif, , France

Site Status

Local Institution - 012-219

Bad Berka, , Germany

Site Status

Universitatsklinikum Bonn

Bonn, , Germany

Site Status

Klinikum Koln-Merheim

Cologne, , Germany

Site Status

Local Institution - 012-210

Essen, , Germany

Site Status

Local Institution - 012-214

Gauting, , Germany

Site Status

Local Institution - 012-671

Giessen, , Germany

Site Status

LungenClinic Grosshansdorf

Grohansdorf, , Germany

Site Status

Local Institution - 012-215

Halle, , Germany

Site Status

Universitatsklinikum Jena

Jena, , Germany

Site Status

Klinikum Kassel

Kassel, , Germany

Site Status

Local Institution - 012-224

Löwenstein, , Germany

Site Status

Local Institution - 012-216

Lübeck, , Germany

Site Status

Local Institution - 012-220

München, , Germany

Site Status

Local Institution - 012-672

Offenbach, , Germany

Site Status

Pius-Hospital Oldenburg

Oldenburg, , Germany

Site Status

Henry Dunant Hospital Center

Athens, Attica, Greece

Site Status

Local Institution - 012-236

Athens, , Greece

Site Status

University General Hospital of Heraklion (PAGNI)

Heraklion, , Greece

Site Status

Local Institution - 012-235

Larissa, , Greece

Site Status

"General Oncology Hospital of Kifisias "Agioi Anargyroi""

Nea Kifissia, , Greece

Site Status

Local Institution - 012-234

Piraeus, , Greece

Site Status

Metropolitan Hospital

Piraeus, , Greece

Site Status

BioClinic Thessaloniki

Thessaloniki, , Greece

Site Status

Local Institution - 012-230

Thessaloniki, , Greece

Site Status

Local Institution - 012-500

Thessaloniki, , Greece

Site Status

Anassa General Clinic

Volos, , Greece

Site Status

Humanity & Health Clinical Trial Centre

Central, , Hong Kong

Site Status

Prince of Wales Hospital - Hong Kong

Hong Kong, , Hong Kong

Site Status

Hong Kong United Oncology Centre

Kowloon, , Hong Kong

Site Status

Local Institution - 012-242

Budapest, , Hungary

Site Status

Local Institution - 012-244

Budapest, , Hungary

Site Status

Local Institution - 012-241

Budapest, , Hungary

Site Status

Local Institution - 012-243

Gyöngyös, , Hungary

Site Status

Local Institution - 012-763

Gyula, , Hungary

Site Status

Local Institution - 012-759

Székesfehérvár, , Hungary

Site Status

Reformatus Pulmonologiai Centrum

Törökbálint, , Hungary

Site Status

The Meath Foundation

Tallaght, Dublin, Ireland

Site Status

St. Vincents University Hospital

Dublin, , Ireland

Site Status

Beaumont Hospital - Dublin

Dublin, , Ireland

Site Status

St. Jamess Hospital

Dublin, , Ireland

Site Status

University Hospital Galway

Galway, , Ireland

Site Status

University Hospital Limerick

Limerick, , Ireland

Site Status

Local Institution - 012-276

Alessandria, , Italy

Site Status

Local Institution - 012-292

Avellino, , Italy

Site Status

Local Institution - 012-274

Aviano, , Italy

Site Status

Local Institution - 012-275

Bari, , Italy

Site Status

Local Institution - 012-765

Brescia, , Italy

Site Status

Local Institution - 012-286

Candiolo, , Italy

Site Status

Local Institution - 012-284

Catania, , Italy

Site Status

Local Institution - 012-282

Catania, , Italy

Site Status

Local Institution - 012-762

Florence, , Italy

Site Status

Local Institution - 012-273

Genova, , Italy

Site Status

Local Institution - 012-285

Genova, , Italy

Site Status

Local Institution - 012-279

Lecce, , Italy

Site Status

"Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST"

Meldola, , Italy

Site Status

Local Institution - 012-296

Milan, , Italy

Site Status

Local Institution - 012-278

Milan, , Italy

Site Status

Local Institution - 012-283

Milan, , Italy

Site Status

Local Institution - 012-271

Napoli, , Italy

Site Status

Local Institution - 012-277

Napoli, , Italy

Site Status

Local Institution - 012-770

Novara, , Italy

Site Status

Local Institution - 012-272

Parma, , Italy

Site Status

Local Institution - 012-281

Perugia, , Italy

Site Status

Local Institution - 012-766

Pesaro, , Italy

Site Status

Local Institution - 012-767

Ravenna, , Italy

Site Status

Local Institution - 012-295

Roma, , Italy

Site Status

Local Institution - 012-758

Verona, , Italy

Site Status

Local Institution - 012-306

Amsterdam, , Netherlands

Site Status

Amphia Ziekenhuis - Breda Molengracht

Breda, , Netherlands

Site Status

Local Institution - 012-300

Maastricht, , Netherlands

Site Status

Local Institution - 012-630

Nijmegen, , Netherlands

Site Status

Local Institution - 012-308

The Hague, , Netherlands

Site Status

Local Institution - 012-307

Utrecht, , Netherlands

Site Status

Universitair Medisch Centrum Utrecht

Utrecht, , Netherlands

Site Status

Instytut MSF

Lodz, , Poland

Site Status

Local Institution - 012-321

Lublin, , Poland

Site Status

Local Institution - 012-760

Lublin, , Poland

Site Status

Local Institution - 012-325

Otwock, , Poland

Site Status

Local Institution - 012-320

Rzeszów, , Poland

Site Status

Local Institution - 012-324

Skorzewo, , Poland

Site Status

Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu

Torun, , Poland

Site Status

Local Institution - 012-322

Warsaw, , Poland

Site Status

Wojskowy Instytut Medyczny

Warsaw, , Poland

Site Status

Unidade Local de Saude de Almada-Seixal, E. P. E (Hospital Garcia de Orta)

Almada, , Portugal

Site Status

Unidade Local de Saude de Braga, E. P. E (Hospital de Braga)

Braga, , Portugal

Site Status

Local Institution - 012-330

Coimbra, , Portugal

Site Status

Local Institution - 012-645

Coimbra, , Portugal

Site Status

Local Institution - 012-333

Guimarães, , Portugal

Site Status

Local Institution - 012-642

Lisbon, , Portugal

Site Status

Local Institution - 012-338-A

Lisbon, , Portugal

Site Status

The Champalimaud Centre for the Unknown

Lisbon, , Portugal

Site Status

Local Institution - 012-338

Lisbon, , Portugal

Site Status

Unidade Local de Saude de Loures-Odivelas, EPE (Hospital Beatriz Angelo)

Loures, , Portugal

Site Status

Hospital CUF Porto

Porto, , Portugal

Site Status

Local Institution - 012-331

Porto, , Portugal

Site Status

Local Institution - 012-339

Porto, , Portugal

Site Status

Unidade Local de Saude de Entre Douro e Vouga, E. P. E

Santa Maria da Feira, , Portugal

Site Status

Unidade Local de Saude da Arrabida, E. P. E (Centro Hospitalar de Setubal)

Setúbal, , Portugal

Site Status

Unidade Local de Saude de Gaia/Espinho, E. P. E

Vila Nova de Gaia, , Portugal

Site Status

Puerto Rico Medical Research Center

San Juan, , Puerto Rico

Site Status

FDI Clinical Research (Fundacion de Investigacion de Diego) - San Juan

San Juan, , Puerto Rico

Site Status

PanOncology Trials - Rio Piedras Medical Center

San Juan, , Puerto Rico

Site Status

Spitalul Jude�ean de Urgen�a dr. Constantin Opri� Baia Mare

Baia Mare, , Romania

Site Status

SC Policlinica de Diagnostic Rapid SA

Brasov, , Romania

Site Status

Centrul Oncologic Sanador

Bucharest, , Romania

Site Status

Local Institution - 012-342

Bucharest, , Romania

Site Status

Local Institution - 012-344

Cluj-Napoca, , Romania

Site Status

Local Institution - 012-340

Cluj-Napoca, , Romania

Site Status

Oncolab Craiova

Craiova, , Romania

Site Status

Local Institution - 012-343

Craiova, , Romania

Site Status

Local Institution - 012-513

Iași, , Romania

Site Status

Ovidius Clinical Hospital

Ovidiu, , Romania

Site Status

Oncocenter - Oncologie Clinica

Timișoara, , Romania

Site Status

SC OncoMed SRL

Timișoara, , Romania

Site Status

Evimed Oncology Clinic

Chelyabinsk, , Russia

Site Status

"Budgetary Healthcare Institution of the Udmurt Republic "Republican Clinical Oncological Dispensary n.a. Sergey Grigoryevich Pr

Izhevsk, , Russia

Site Status

"Regional Budgetary Healthcare Institution "G.E. Ostroverkhov Kursk Oncology Scientific and Clinical Center" of the Healthcare C

Kislino Village, , Russia

Site Status

VitaMed - Moscow

Moscow, , Russia

Site Status

University Headache Clinic

Moscow, , Russia

Site Status

State Budgetary Healthcare Institution of the Nizhny Novgorod Region Clinical Diagnostic Center

Nizhny Novgorod, , Russia

Site Status

"Limited Liability Company Medical Sanitary Unit "Clinicist-Clinic Pretor""

Novosibirsk, , Russia

Site Status

"Budgetary Healthcare Institution of Omsk region "Clinical Oncologic Dispensary""

Omsk, , Russia

Site Status

Local Institution - 012-355

Saint Petersburg, , Russia

Site Status

"Federal State Budgetary Institution "Influenza Research Institute named after N.N. A.A. Smorodintsev" of the Ministry of Health

Saint Petersburg, , Russia

Site Status

Local Institution - 012-354

Saint Petersburg, , Russia

Site Status

Local Institution - 012-093

Singapore, , Singapore

Site Status

Raffles Hospital

Singapore, , Singapore

Site Status

Icon Cancer Centre Farrer Park

Singapore, , Singapore

Site Status

Oncocare Cancer Centre

Singapore, , Singapore

Site Status

Parkway Cancer Centre - Gleneagles Hospital

Singapore, , Singapore

Site Status

Local Institution - 012-111

Busan, , South Korea

Site Status

Local Institution - 012-522

Busan, , South Korea

Site Status

Local Institution - 012-101

Busan, , South Korea

Site Status

Chungbuk National University Hospital

Cheongju-si, , South Korea

Site Status

Local Institution - 012-110

Daegu, , South Korea

Site Status

Local Institution - 012-523

Daegu, , South Korea

Site Status

Local Institution - 012-100

Hwasun-gun, , South Korea

Site Status

Local Institution - 012-103

Incheon, , South Korea

Site Status

Local Institution - 012-102

Junggu, , South Korea

Site Status

Local Institution - 012-520

Seongnam-si, , South Korea

Site Status

Local Institution - 012-112

Seongnam-si, , South Korea

Site Status

Korea University Anam Hospital

Seoul, , South Korea

Site Status

Local Institution - 012-118

Seoul, , South Korea

Site Status

Local Institution - 012-106

Seoul, , South Korea

Site Status

Asan Medical Center

Seoul, , South Korea

Site Status

The Catholic University of Korea - Seoul St. Marys Hospital

Seoul, , South Korea

Site Status

Catholic University of Korea St. Vincents Hospital

Suwon, , South Korea

Site Status

Local Institution - 012-107

Suwon, , South Korea

Site Status

Clinica Universidad de Navarra - Pamplona

Pamplona, Navarre, Spain

Site Status

Local Institution - 012-613

A Coruña, , Spain

Site Status

Local Institution - 012-769

Alicante, , Spain

Site Status

Hospital Germans Trias i Pujol

Badalona, , Spain

Site Status

Local Institution - 012-776

Barakaldo, , Spain

Site Status

Hospital del Mar - Parc de Salut Mar

Barcelona, , Spain

Site Status

Local Institution - 012-614

Barcelona, , Spain

Site Status

Local Institution - 012-612

Barcelona, , Spain

Site Status

Local Institution - 012-600

Barcelona, , Spain

Site Status

Local Institution - 012-621

Córdoba, , Spain

Site Status

Local Institution - 012-764

Girona, , Spain

Site Status

Local Institution - 012-616

Granada, , Spain

Site Status

Complejo Hospitalario Universitario Insular Materno Infantil

Las Palmas de Gran Canaria, , Spain

Site Status

Hospital de Leon

León, , Spain

Site Status

Local Institution - 012-615

Lugo, , Spain

Site Status

Local Institution - 012-607

Madrid, , Spain

Site Status

Clinica Universidad de Navarra - Madrid

Madrid, , Spain

Site Status

Local Institution - 012-606

Madrid, , Spain

Site Status

Local Institution - 012-601

Madrid, , Spain

Site Status

Local Institution - 012-609

Madrid, , Spain

Site Status

Hospital Universitario 12 de Octubre

Madrid, , Spain

Site Status

Local Institution - 012-626

Majadahonda, , Spain

Site Status

Local Institution - 012-608

Málaga, , Spain

Site Status

Local Institution - 012-602

Palma de Mallorca, , Spain

Site Status

Local Institution - 012-604

Santander, , Spain

Site Status

Local Institution - 012-629

Seville, , Spain

Site Status

Consorci Hospital General Universitari de Valencia

Valencia, , Spain

Site Status

Hospital Universitari i Politecnic La Fe

Valencia, , Spain

Site Status

Local Institution - 012-603

Zaragoza, , Spain

Site Status

Universitatsspital Basel

Basel, , Switzerland

Site Status

Spital Simmental-Thun-Saanenland

Thun, , Switzerland

Site Status

Kantonsspital Winterthur

Winterthur, , Switzerland

Site Status

University Hospitals Birmingham NHS Foundation Trust

Birmingham, , United Kingdom

Site Status

NHS Lothian

Edinburgh, , United Kingdom

Site Status

NHS Greater Glasgow and Clyde

Glasgow, , United Kingdom

Site Status

University Hospitals of Leicester NHS Trust

Leicester, , United Kingdom

Site Status

The Christie NHS Foundation Trust

Manchester, , United Kingdom

Site Status

Countries

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United States Australia Austria Belgium Czechia France Germany Greece Hong Kong Hungary Ireland Italy Netherlands Poland Portugal Puerto Rico Romania Russia Singapore South Korea Spain Switzerland United Kingdom

References

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Barlesi F, Yao W, Duruisseaux M, Doucet L, Martinez AA, Gregorc V, Juan-Vidal O, Lu S, De Bondt C, de Marinis F, Linardou H, Kim YC, Jotte R, Felip E, Lo Russo G, Reck M, Michenzie MF, Yang W, Meade JN, Korytowsky B, Mok TSK; KRYSTAL-12 Investigators. Adagrasib versus docetaxel in KRASG12C-mutated non-small-cell lung cancer (KRYSTAL-12): a randomised, open-label, phase 3 trial. Lancet. 2025 Aug 9;406(10503):615-626. doi: 10.1016/S0140-6736(25)00866-9.

Reference Type DERIVED
PMID: 40783289 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Related Links

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Other Identifiers

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CA239-0013

Identifier Type: OTHER

Identifier Source: secondary_id

849-012

Identifier Type: OTHER

Identifier Source: secondary_id

CA239-0013

Identifier Type: -

Identifier Source: org_study_id

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