Levofloxacin Ocular Implant for Ocular Surgery

NCT ID: NCT04682288

Last Updated: 2021-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-04

Study Completion Date

2021-10-14

Brief Summary

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This is a multi center, open label, interventional study in one eye of 5 subjects scheduled for uncomplicated cataract surgery with administration of a single Levofloxacin Ocular Implant in the posterior sulcus of the surgical eye at the end of cataract surgery.

Detailed Description

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Conditions

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Cataract

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Levofloxacin Ocular Implant

Biphasic levofloxacin antibiotic implant

Group Type EXPERIMENTAL

Levofloxacin Ocular Implant

Intervention Type DRUG

Levofloxacin Ocular Implant an implant that delivers a bolus dose of levofloxacin and a constant daily dose for a further 5-7 days.

Interventions

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Levofloxacin Ocular Implant

Levofloxacin Ocular Implant an implant that delivers a bolus dose of levofloxacin and a constant daily dose for a further 5-7 days.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of cataract in the intent to treat eye
* Endothelial cell density in the study eye of at least 2000 cells per mm2

Exclusion Criteria

* history of ocular inflammation including, macular degeneration, uveitis, macular edema or corneal edema
* recent surgery in the study eye
* subjects receiving a glaucoma device in conjunction with cataract surgery
* subjects with a compromised posterior capsule during surgery
* corneal disease that prevents effective imaging of endothelium including Fuch's Dystrophy.
* sensitivity to fluoroquinolones
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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PolyActiva Pty Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Joseph Gira, MD

Role: PRINCIPAL_INVESTIGATOR

Opthalmology Consultants Ltd

Locations

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Ophthalmology Consultants Ltd

St Louis, Missouri, United States

Site Status

Carolina Cataract and Laser Centre

Ladson, South Carolina, United States

Site Status

Melbourne Eye Specialists

Fitzroy, Victoria, Australia

Site Status

Countries

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United States Australia

Other Identifiers

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LEVO-CS101

Identifier Type: -

Identifier Source: org_study_id